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Product FOB Price Min.Order Supply Ability Supplier
High quality Hydroxypropyl methyl cellulose 99% with best price
Cas No: 9004-65-3
USD $ 30.0-40.0 / Kilogram 1 Kilogram 5000 Kilogram/Month Kono Chem Co.,Ltd Contact Supplier
Hydroxypropyl methyl cellulose
Cas No: 9004-65-3
No Data 1 Gram 1-1000 Metric Ton/Day Hangzhou Dayangchem Co., Ltd. Contact Supplier
Hydroxypropyl Methyl Cellulose
Cas No: 9004-65-3
USD $ 8.0-8.2 / Kilogram 1 Kilogram 5000 Metric Ton/Year Shanghai Runkey Biotech Co., Ltd. Contact Supplier
Empty vegetable capsules clear size 0 1 2 3
Cas No: 9004-65-3
No Data 100 Kilogram 3000 Metric Ton/Year XI AN FORTA CHEM CO.,LTD Contact Supplier
Best HPMC;Hydroxypropyl methyl cellulose supplier
Cas No: 9004-65-3
No Data 10 Gram 1500 Kilogram/Month Jilin BaiShengYuan Import and Export Trade Co., Ltd. Contact Supplier
Adhesive MHPC/Hypromellose
Cas No: 9004-65-3
No Data 25 Kilogram 600 Kilogram/Month Shijiazhuang Fanrui Logistics Co., Ltd. Contact Supplier
Hydroxy Propyl Methyl Cellulose
Cas No: 9004-65-3
USD $ 20.0-30.0 / Gram 10 Gram 200 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
Hydroxypropyl Methyl Cellulose Manufacturer 9004-65-3 For Ophthalmic Medication
Cas No: 9004-65-3
No Data 10 Gram 10000 Metric Ton/Month Hubei XinRunde Chemical Co., Ltd Contact Supplier
Hydroxypropyl methyl cellulose
Cas No: 9004-65-3
No Data 50 Kilogram 10 Metric Ton/Day PUYANG WANQUAN CHEMICAL CO.,LTD. Contact Supplier
Building Mortar Adhesive HPMC
Cas No: 9004-65-3
No Data 2 Metric Ton 8000 Metric Ton/Month Cangzhou Bao Lai Da Import&Export Trading Co.,Ltd Contact Supplier

9004-65-3 Usage


A thickener for aqueous and non-aqueous systems.

Limited use

FAO/WHO (1984): Cold drink ,10g/kg (in the end product design, single use or with other emulsifier, stabilizer and thickener dosage).
GB 2760-96: all kinds of food, to GMP limited.


As emulsifier, film former, protective colloid, stabilizer, suspending agent, or thickener in foods. Pharmaceutic aid (suspending agent; tablet excipient; demulcent; viscosity increasing agent); hydrophilic carrier in drug delivery systems. In adhesives, asphalt emulsions, caulking compounds, tile mortars, plastic mixes, cements, paints.

Methods of production

1.The refined cotton cellulose with alkali treatment at 35-40 ℃ for half an hour, press, crushed the cellulose, aging at 35 ℃, so that the average degree of polymerization of alkali cellulose is in a desired range. The alkali fiber into etherification reactor, followed by adding epoxy propane and methane chloride, etherification at 50-80 ℃ for 5h, the maximum pressure is about 1.8MPa. The reaction products were produced by postprocessing (hydrochloric acid and oxalic acid, washing and drying). The consumption of raw material of cotton pulp 1100kg/t, methyl chloride and propylene oxide 4300kg/t, solid alkali 1200kg/t, hydrochloride 30kg/t, oxalic acid 50kg/t.
2.100 kg refined cotton linters immersed in 45% solution, temperature is 35 to 40℃, time is 0.5 to 1 h, and then remove the press. The pressure to weight is 2.7 times as the weight of lint, stop pressure. Carry out the crushing. At 35℃, aging for 16h.
In the reaction kettle, the chlorinated methane, propylene oxide were added into the reaction kettle. At 80℃, the pressure was 1.8 MPa, the reaction time is 5 to 8 h, and the amount of hydrochloric acid and oxalic acid were added to the hot water at 90℃. Dewatering with centrifuge, washing to neutral, when the water content of the material is below to 60% , 130℃ of hot air flow dried to the moisture content is below 5%. Finally, the finished product sieved by 20 mesh.
3. Prepared by cellulose, methyl chloride, and ethylene oxide.

Identification test

It is soluble in water swelling, forming a transparent milky white sticky gel solution, and insoluble in ethanol.

Product features

Hydroxypropyl methyl cellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.It is white or pale white cellulose powder or particles. The characteristics of cold water dissolution and hot water insoluble are similar with methyl cellulose. Solubility in organic solvents is superior than water soluble, can be dissolved in anhydrous methanol and ethanol solution, also soluble in chlorinated hydrocarbons and ketones in organic solvents. Soluble in water, its water solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the reversible conversion of sol to gel. Can be used alone in the cold drink, also can be used with other emulsifier, stabilizer. To cold drink, the maximum amount is 1%. Hydroxypropyl methyl cellulose and other water-soluble high weight compounds use mixture, become transparent, higher viscosity. The gelation temperature of low viscosity products is higher than high viscosity of products. Its solution is stable at room temperature. In recent years, It has been widely used in petroleum chemical industry, papermaking, leather, textile printing and dyeing, pharmaceutical, food, cosmetics and other industries, and as the dispersing agent, thickening agent, adhesive, excipient, capsule, oil resistant coating and packing etc.
The molecular structure of hydroxypropyl methyl cellulose
Figure 1 The molecular structure of hydroxypropyl methyl cellulose

Ophthalmic remedy

[Application] Through the stability and thickening of anterior corneal tear, it can promote corneal moist, cut off time, extend the tear film in dry eyes and can prolong the retention time of tear film. It used for the lack of clinical tear caused by dry eyes and eye irritation, and the treatment of keratoconjunctivitis sicca, exposure keratitis and Neuroparalytic keratitis to prevent corneal injury. It can be used for hard contact lenses or artificial eye lubricant. For gonioscopy, contact endoscopy and surgery, it is as a medium in condensation genioplasty or retinal laser iridectomy in the process to protect the cornea.
[dosage] eye: 0.3%~1% solution, 1 drops, 3~4 times /d. 2% of the solution is used for the anterior chamber angle.
[Attention and taboo] Using it can sometimes have blurred vision or eyelid adhesion feeling. Continuous time should not exceed 3 Days. Wearing soft contact lens is banned to corneal epithelial disease. Wear a hard contact lens should prevent the lens floating.
[Specification] eye drops: 0.3%, 0.5%, 1%, 2.5%.
This information is edited by Chemicalbook Xiannan (2015-08-31).

Chemical property

Hydroxypropyl methyl cellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.It is white or pale white cellulose powder or particles.It has different types of products, the methoxy and hydroxypropyl content ratio is different. It is white or gray fibrous powder or particles. It is soluble in water and some organic solvents and unsoluble in ethanol. Aqueous solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the sol to gel reversible transformation.

Chemical Properties

white or slightly beige powder or a viscous solution

Usage method

Purpose: thickener, emulsifier, stabilizer.
1 note: hydroxypropyl methyl cellulose has many excellent properties. It can be used for baking food, pasty food, enriched food, milk paste mixing drinks, pie fillings, toppings, salad and fast food. The use of its thermal gel properties can make deep fried food, not only can save a lot of oil, but also the product has a unique taste of the soft. The use of its acid, alkali stability, anti-enzymes, do not participate in metabolism, enhance the characteristics of gastrointestinal motility, but also used to produce a variety of health food.
2 usage range and usage
(1) The provisions on the use of hygienic standards for food additives (GB 2760-1996) shall be used in all kinds of food appropriately.
(2) The actual use of reference: the use of high transparency film and film of this product can be used in the manufacture of casings, dosage is 5%. It is used as a thickener mayonnaise (HPMC-60RT400), dosage of 0.5%~2%.


ADI does not make special provisions (FAO/WHO, 2001). It can be used for food safety (FDA. §172.87, 2000). LD505200mg/kg (rats, intra peritoneal injection).


1. Thickener, stabilizer, emulsifier, emulsifier, suspending agent.
2. It is used as a synthetic resin dispersing agent, and the coating agent,also used as a thickener.
3. This product is used as a thickener, dispersant, binder, emulsifier and stabilizer in the textile industry. It is also widely used in synthetic resin, petrochemical, ceramics, paper, leather, medicine, food, cosmetics and other industries.
4. Used in synthetic resin, petroleum chemical industry, ceramics, paper, leather, textile, medicine, food, cosmetics and other daily chemicals and as dispersing agent, thickening agent, binders, excipients, capsules, oil resistant coating and packing etc.


Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

9004-65-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (423173)  (Hydroxypropyl)methylcellulose  average Mn ~120,000 9004-65-3 423173-100G 1,072.89CNY Detail
Aldrich (423181)  (Hydroxypropyl)methylcellulose  average Mn ~90,000 9004-65-3 423181-100G 1,202.76CNY Detail
Aldrich (423203)  (Hydroxypropyl)methylcellulose  average Mn ~86,000 9004-65-3 423203-100G 1,083.42CNY Detail
Aldrich (423238)  (Hydroxypropyl)methylcellulose  average Mn ~10,000 9004-65-3 423238-100G 1,081.08CNY Detail
Aldrich (423238)  (Hydroxypropyl)methylcellulose  average Mn ~10,000 9004-65-3 423238-25G 518.31CNY Detail
USP (1330005)  Hypromellose  United States Pharmacopeia (USP) Reference Standard 9004-65-3 1330005-250MG 4,662.45CNY Detail
Sigma-Aldrich (H3785)  Hypromellose  meets USP testing specifications 9004-65-3 H3785-250G 3,332.16CNY Detail
Sigma-Aldrich (H3785)  Hypromellose  meets USP testing specifications 9004-65-3 H3785-100G 1,666.08CNY Detail
Sigma-Aldrich (H3785)  Hypromellose  meets USP testing specifications 9004-65-3 H3785-25G 664.56CNY Detail
Sigma (09965)  (Hydroxypropyl)methylcellulose   9004-65-3 09965-500G 2,331.81CNY Detail
Sigma (09963)  (Hydroxypropyl)methylcellulose   9004-65-3 09963-500G 2,455.83CNY Detail
Sigma (09963)  (Hydroxypropyl)methylcellulose   9004-65-3 09963-100G 1,041.30CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name Hypromellose

1.2 Other means of identification

Product number -
Other names HPMC

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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