90043-50-8Relevant academic research and scientific papers
Cu-catalyzed sequential dehydrogenation-conjugate addition for β-functionalization of saturated ketones: Scope and mechanism
Jie, Xiaoming,Shang, Yaping,Zhang, Xiaofeng,Su, Weiping
supporting information, p. 5623 - 5633 (2016/05/24)
The first copper-catalyzed direct β-functionalization of saturated ketones is reported. This protocol enables diverse ketones to couple with a wide range of nitrogen, oxygen and carbon nucleophiles in generally good yields under operationally simple conditions. The detailed mechanistic studies including kinetic studies, KIE measurements, identification of reaction intermediates, EPR and UV-visible experiments were conducted, which reveal that this reaction proceeds via a novel radical-based dehydrogenation to enone and subsequent conjugate addition sequence.
CaCl2, Bisoxazoline, and Malonate: A Protocol for an Asymmetric Michael Reaction
Lippur, Kristin,Kaabel, Sandra,J?rving, Ivar,Rissanen, Kari,Kanger, T?nis
, p. 6336 - 6341 (2015/06/30)
A mild protocol for the asymmetric Michael addition of dimethyl malonate to various α,β-unsaturated carbonyl compounds was developed. The salient feature of this methodology is that a cheap and environmentally friendly Lewis acid, CaCl2, was used as a catalyst. An aminoindanol- and pyridine-derived ligand provided in the presence of CaCl2 Michael adducts in moderate to high enantioselectivities. The scope of the reaction was demonstrated.
Organocatalytic asymmetric addition of malonates to unsaturated 1,4-diketones
Zari, Sergei,Kailas, Tiiu,Kudrjashova, Marina,Oeeren, Mario,Jaerving, Ivar,Tamm, Toomas,Lopp, Margus,Kanger, Tonis
supporting information, p. 1452 - 1457 (2012/11/07)
The organocatalytic Michael addition of malonates to symmetric unsaturated 1,4-diketones catalyzed by thiourea and squaramide derivatives with Cinchona alkaloids afforded the formation of a new C-C bond in high yields (up to 98%) and enantiomeric purities (up to 93%). The absolute configuration of the product was suggested from comparison of the experimental and calculated VCD spectra of the reaction product 3a.
Michael adducts - Source for biologically potent heterocycles
Padmaja, Adivireddy,Reddy, Gali Sudhakar,Venkata Nagendra Mohan, Annaji,Padmavathi, Venkatapuram
, p. 647 - 653 (2008/09/21)
A new class of pyrimidinetriones, thioxopyrimidinediones, pyrazolidinediones and isoxazolidinediones were prepared from (E)-1,4-diarylbut-2-ene-1,4-diones. All the new compounds synthesized were screened for antimicrobial activity.
Chiral bicyclic guanidines: A concise and efficient aziridine-based synthesis
Ye, Weiping,Leow, Dasheng,Goh, Serena Li Min,Tan, Chin-Tong,Chian, Chee-Hoe,Tan, Choon-Hong
, p. 1007 - 1010 (2007/10/03)
A series of chiral bicyclic guanidines, either symmetrical or non-symmetrical, was synthesized using a concise and efficient aziridine-based synthetic methodology. Starting from commercial amino alcohols, five synthetic steps were performed, with only thr
1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) catalyzed Michael reactions
Ye, Weiping,Xu, Junye,Tan, Chin-Tong,Tan, Choon-Hong
, p. 6875 - 6878 (2007/10/03)
1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD), a bicyclic guanidine base, has been found to be an excellent catalyst for Michael and Michael-type reactions. A wide variety of Michael donors and acceptors can participate in these reactions using 10-20 mol % of
