900504-92-9

Basic information

• Product Name: N-[1-(4-chloro-5-fluoro-2-nitro-phenyl)-ethyl]-2,2,2-trifluoro-acetamide
• CAS NO: 900504-92-9
• Molecular Weight: 314.624
• Mol File: 900504-92-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[1-(4-chloro-5-fluoro-2-nitro-phenyl)-ethyl]-2,2,2-trifluoro-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-(4-chloro-5-fluoro-2-nitro-phenyl)-ethyl]-2,2,2-trifluoro-acetamide(900504-92-9)
• EPA Substance Registry System: N-[1-(4-chloro-5-fluoro-2-nitro-phenyl)-ethyl]-2,2,2-trifluoro-acetamide(900504-92-9)

Safety Data

• Hazardous Substances Data: 900504-92-9(Hazardous Substances Data)

Upstream product

• 5527-95-7 4-chloro-3-fluorobenzaldehyde 
• 787633-86-7 2-[1-(4-Chloro-3-fluoro-phenyl)-ethyl]-isoindole-1,3-dione 
• 339001-14-8 1-(4-chloro-3-fluoro-phenyl)-ethanol 
• 787633-87-8 1-(4-Chloro-3-fluoro-phenyl)-ethylamine 
• 787633-88-9 N-[1-(4-chloro-3-fluoro-phenyl)-ethyl]-2,2,2-trifluoro-acetamide 

Downstream Products

• 900505-07-9 1-(4-chloro-5-fluoro-2-nitro-phenyl)-ethylamine 

Relevant articles and documents

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity

The disruption of the p53-Hdm2 protein-protein interaction induces cell growth arrest and apoptosis. We have identified the 1,4-benzodiazepine-2,5-dione scaffold as a suitable template for inhibiting this interaction by binding to the Hdm2 protein. Several compounds have been made with improved potency, solubility, and cell-based activities.