900522-85-2Relevant articles and documents
Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations
Bremner, John B.,Keller, Paul A.,Pyne, Stephen G.,Robertson, Mark J.,Sakthivel,Somphol, Kittiya,Baylis, Dean,Coates, Jonathan A.,Deadman, John,Jeevarajah, Dharshini,Rhodes, David I.
, p. 1265 - 1270 (2012/09/25)
The facile synthesis of seven new dicationic tripeptide benzyl ester derivatives, with hydrophobic group variations in the C-terminal amino acid component, is described. Moderate to good activity was seen against Gram-positive bacteria in vitro. One cyclohexylsubstituted compound 2c was tested more widely and showed good potency (MIC values ranging from 2-4 μg/mL) against antibiotic-resistant strains of Staphylococcus aureus and Enterococci (VRE, VSE), and against Staphylococcus epidermidis.