900641-76-1

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2-METHOXY-5-METHYLAMINOBENZOATE is used as a chemical intermediate for the synthesis of various medications, particularly those aimed at treating pain and inflammation. Its potential analgesic and anti-inflammatory properties make it an essential component in the development of new drugs.
Used in Food Industry:
METHYL 2-METHOXY-5-METHYLAMINOBENZOATE is used as a flavoring agent due to its pleasant aroma and taste, enhancing the sensory experience of food products.

Upstream product

• 89-56-5 5-Methylsalicylic acid 
• 63113-79-1 methyl 2-methoxy-5-methylbenzoate 
• 98165-65-2 methyl 5-(bromomethyl)-2-methoxybenzoate 
• 1610862-12-8 (E)-methyl 2-methoxy-5-((methoxyimino)methyl)benzoate 
• 78515-16-9 methyl 5-formyl-2-methoxybenzoate 
• 41489-76-3 methyl-5-formyl-2-hydroxybenzoate 
• 616-76-2 2-hydroxy-5-formylbenzoic acid 

Downstream Products

• 1610862-10-6 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-methoxy-5-(methylsulfonamidomethyl)benzoyloxy)ethyl)pyridine 1-oxide 
• 1616491-12-3 ethyl 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1616491-35-0 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1616491-36-1 1-(4-hydroxy-3-(methoxycarbonyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1616491-37-2 methyl-5-((3-(benzylcarbamoyl)-6-iodo-4-oxoquinolin-1(4H)-yl)methyl)-2-methoxybenzoate 
• 1616491-11-2 (Z)-methyl5-(((2-(2-chloro-5-iodobenzoyl)-3-ethoxy-3-oxoprop-1-en-1-yl)amino)methyl)-2-methoxybenzoate 
• 1610862-09-3 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-methoxy-5-((N-(2-morpholinoethyl)-methylsulfonamido)methyl)benzoyloxy)ethyl)pyridine 1-oxide 
• 1610862-11-7 2-methoxy-5-(methylsulfonamidomethyl)benzoic acid 

Relevant academic research and scientific papers

1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS

Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.

4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B

Protein tyrosine phosphatase 1B is a negative regulator in the insulin and leptin signaling pathways, and has emerged as an attractive target for the treatment of type 2 diabetes and obesity. However, the essential pharmacophore of charged phosphotyrosine or its mimetic confer low selectivity and poor cell permeability. Starting from our previously reported aryl diketoacid-based PTP1B inhibitors, a drug-like scaffold of 4-quinolone-3-carboxylic acid was introduced for the first time as a novel surrogate of phosphotyrosine. An optimal combination of hydrophobic groups installed at C-6, N-1 and C-3 positions of the quinolone motif afforded potent PTP1B inhibitors with low micromolar IC 50 values. These 4-quinolone-3-carboxylate based PTP1B inhibitors displayed a 2-10 fold selectivity over a panel of PTP's. Furthermore, the bidentate inhibitors of 4-quinolone-3-carboxylic acids conjugated with aryl diketoacid or salicylic acid were cell permeable and enhanced insulin signaling in CHO/hIR cells. The kinetic studies and molecular modeling suggest that the 4-quinolone-3-carboxylates act as competitive inhibitors by binding to the PTP1B active site in the WPD loop closed conformation. Taken together, our study shows that the 4-quinolone-3-carboxylic acid derivatives exhibit improved pharmacological properties over previously described PTB1B inhibitors and warrant further preclinical studies.