900714-64-9Relevant academic research and scientific papers
A concise and versatile synthesis of viridicatin alkaloids from cyanoacetanilides
Kobayashi, Yusuke,Harayama, Takashi
supporting information; experimental part, p. 1603 - 1606 (2009/08/07)
The efficient synthesis of 3-hydroxy-4-arylquinolin-2(1H)-ones through one-pot Knoevenagel condensation/epoxidation of cyanoacetanilides followed by decyanative epoxide-arene cyclization is described. A convergent assembly with functionalized aldehydes allows for rapid synthesis with diverse substitution patterns. Isolation of 3-hydroxy-4-arylquinolin-2(1H)-ones is readily accomplished by precipitation and filtration.
