900790-27-4Relevant academic research and scientific papers
Thiourea-catalyzed direct reductive amination of aldehydes
Menche, Dirk,Arikan, Fatih
, p. 841 - 844 (2006)
A hydrogen-bond-catalyzed direct reductive amination of aldehydes is reported. The acid- and metal-free process uses thiourea as organocatalyst and the Hantzsch ester for transfer-hydrogenation and allows for the high-yielding synthesis of diverse amines. Georg Thieme Verlag Stuttgart.
Efficient access to cyclic ureas via Pd-catalyzed cyclization
McLaughlin, Mark,Palucki, Michael,Davies, Ian W.
, p. 3311 - 3314 (2007/10/03)
An efficient regioselective method for the preparation of structurally diverse imidazopyridinones and benzoimidazolones starting from readily available and economical starting materials is described. High-yielding reductive alkylation of electron-deficient o-haloarylamines followed by treatment with inexpensive N-chlorosulfonyl isocyanate afforded primary ureas in good overall yields. A Pd-catalyzed urea cyclization reaction furnished imidazopyridinones and benzoimidazolones in excellent yields. Overall, the developed chemistry provides rapid access to pharmaceutically important heterocyclic compounds with high efficiency.
