9008-97-3

Basic information

• Product Name: PHYTOHEMAGGLUTININ PHA-M
• Synonyms: pigeonpeaphytohemagglutinin;LEUCOAGGLUTININ (PHA-L);RED KIDNEY BEAN LECTIN;PHASEOLUS VULGARIS AGGLUTININ;PHASEOLUS VULGARIS AGGLUTININ PHA-L;PHASEOLUS VULGARIS LECTIN;PHASEOLUS VULGARIS LEUCOAGGLUTININ;PHASEOLUS VULGARIS LEUCOAGGLUTININ AGAROSE BOUND
• CAS NO: 9008-97-3
• Molecular Weight: 0
• EINECS: 291-083-4
• Product Categories: Intermediate
• Mol File: 9008-97-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /salt-free, lyophilized powder
• Storage Temp.: 2-8°C
• Solubility: PBS: 2 mg/mL
• CAS DataBase Reference: PHYTOHEMAGGLUTININ PHA-M(CAS DataBase Reference)
• NIST Chemistry Reference: PHYTOHEMAGGLUTININ PHA-M(9008-97-3)
• EPA Substance Registry System: PHYTOHEMAGGLUTININ PHA-M(9008-97-3)

Safety Data

• Safety Statements: 22-24/25
• RTECS: TJ3470000
• F: 10-21
• Hazardous Substances Data: 9008-97-3(Hazardous Substances Data)

Usage

Description

Phytohemagglutinin PHA-M is a lectin protein derived from the kidney bean (Phaseolus vulgaris). It is known for its ability to bind to specific carbohydrate structures on the surface of various cell types, particularly lymphocytes. This property allows it to stimulate the immune system and activate specific types of white blood cells, making it a valuable tool in immunological research and therapeutic applications.

Uses

Used in Immunological Research:
Phytohemagglutinin PHA-M is used as a mitogen for the activation of Jurkat and primary cells. It promotes the proliferation and differentiation of these cells, which is essential for studying immune responses and the behavior of lymphocytes in various experimental settings.
Used in Cancer Immunotherapy:
Phytohemagglutinin PHA-M is used as an immunostimulant in cancer immunotherapy. It has the potential to enhance the immune system's ability to recognize and eliminate cancer cells by activating polymorphonuclear blood cells (PMBCs). This can lead to the development of more effective treatments for various types of cancer.
Used in Drug Delivery Systems:
Although not explicitly mentioned in the provided materials, it is worth noting that lectins like Phytohemagglutinin PHA-M can also be employed in drug delivery systems. They can be used to target specific cell types or tissues, improving the efficacy and reducing the side effects of certain therapeutic agents.

Biochem/physiol Actions

Phytohemagglutinin (PHA) has mitogenic and potent cell agglutinating activities. It binds to T-cell membranes and stimulates cell division and metabolic activity. PHA has the ability to stimulate close contacts between cell membranes.