900802-88-2Relevant academic research and scientific papers
Exploration of orally available calpain inhibitors 2: Peptidyl hemiacetal derivatives
Shirasaki, Yoshihisa,Nakamura, Masayuki,Yamaguchi, Masazumi,Miyashita, Hiroyuki,Sakai, Osamu,Inoue, Jun
, p. 3926 - 3932 (2006)
We previously reported a potent calpain inhibitor 1 (SJA6017, N-(4-fluorophenyl)-L-valyl-L-leucinal), which displayed relatively low oral bioavailability (BA). Replacing the metabolically labile aldehyde moiety of 1 with more chemically stable warheads, s
CYCLIC HEMIACETAL DERIVATIVE AND USE THEREOF
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Page 9, (2010/02/09)
A compound represented by the following formula (I) wherein R1 is a lower alkyl group, R2 is a hydrogen, a halogen, a cyano group, a lower alkyl group or a lower alkoxy group, and n is 0 or 1, which has a calpain inhibitory activity, is provided.
