900809-19-0Relevant academic research and scientific papers
Synthesis and evaluation of N-(4-benzylphenyl)piperazines as VGF inducers
Toba, Tetsuya,Suzuki, Ryosuke,Futamura-Takahashi, Junko,Kawamoto, Yoshito,Tamura, Shigeki,Kuroda, Mariko,Shimmyo, Yoshiari,Kadokura, Michinori,Goto, Kazumichi,Inoue, Teruyoshi,Muto, Tsuyoshi,Annoura, Hirokazu
, p. 2528 - 2532 (2018)
A series of compounds was discovered that induce the production of VGF mRNA in SH-SY5Y cells and exhibit cytoprotection under tunicamycin induced endoplasmic reticulum (ER) stress. The aminophenol ring and linker chain of the template SUN N8075 (1) was modified to yield compounds with higher efficacy and lower propensity for adverse effects.
AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE
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Paragraph 0120, (2014/01/08)
[Problems to be Solved by the Invention] To provide a drug having excellent antibacterial activity against Gram-positive bacteria and Gram-negative bacteria and also being excellent in terms of safety. [Means for Solving the Problems] A compound represented by the following formula (I) or a salt thereof: wherein R represents a hydrogen atom, a hydroxy group, or a halogen atom m represents an integer 0, 1, or 2, n represents an integer 0 or 1 Ar1 represents a bicyclic heterocyclic group represented by the following formula: wherein Aa represents a nitrogen atom or C-Ra, Ab represents a nitrogen atom or C-Rb, and Ac represents a nitrogen atom or C-Rc, Ra, Rb, and Rc independently represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, R1 and R2 independently represent a hydrogen atom, an alkoxy group containing 1 to 6 carbon atoms, a halogenoalkoxy group containing 1 to 6 carbon atoms, a halogen atom, or a cyano group, Ar2 represents a bicyclic heterocyclic group represented by the following formulae:
MITOTIC KINESIN INHIBITORS
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Page/Page column 43, (2008/06/13)
The present invention relates to fluorinated aminoalkyl-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP
MITOTIC KINESIN INHIBITORS
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Page/Page column 37-38, (2008/06/13)
The present invention relates to fluorinated 2-aminomethylquinazolinone derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention al
MITOTIC KINESIN INHIBITORS
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Page/Page column 46, (2008/06/13)
The present invention relates to fluorinated 2-aminomethylthienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention
