90085-44-2Relevant academic research and scientific papers
Synthesis and biological evaluation of potential new inhibitors of the bacterial transferase MraY with a β-ketophosphonate structure
Auberger, Nicolas,Frlan, Rok,Al-Dabbagh, Bayan,Bouhss, Ahmed,Crouvoisier, Muriel,Gravier-Pelletier, Christine,Merrer, Yves Le
scheme or table, p. 8301 - 8312 (2012/04/23)
Stable analogs of bacterial transferase MraY substrate or product with a pyrophosphate surrogate in their structure are described. β- ketophosphonates were designed as pyrophosphate bioisosteres and were investigated as UDP-GlcNAc mimics. The developed st
Rapid and efficient synthesis of unsymmetrical phosphinic acids r′t(o)ohr″
Fougere, Cecile,Guenin, Erwann,Hardouin, Julie,Lecouvey, Marc
experimental part, p. 6048 - 6054 (2010/03/02)
A new synthesis of unsymmetrical phosphinic acids R′P(O)OHR″ has been evaluated, The first P-C bond was formed by base-promoted H-phosphinate alkylation of a protected H-phosphinate, which is easier and safer to handle, A onepot methodology was developed for the second P-C bond formation reaction that: involves the sila-Arbuzov reaction. This methodology was then extended to the synthesis of a dialkylphosphinic acid with an amino functionality.
