900865-72-7Relevant academic research and scientific papers
Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity
Zhao, Ming,Bi, Lanrong,Bi, Wei,Wang, Chao,Yang, Zhe,Ju, Jingfang,Peng, Shiqi
, p. 4761 - 4774 (2006)
3-(S)-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid isolated from A. Chinese G. Don was found to possess moderate anti-aggregation activity, but with poor bioavailability. To improve its pharmacological property, we designed and synthesized a series of
Methyl (11aS)-1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo- [3′,4′:1,2]pyridin[3,4-b]-indol-2-substituted acetates: Synthesis and three-dimensional quantitative structure-activity relationship investigation as a class of novel vasodilators
Liu, Jiawang,Zhao, Ming,Cui, Guohui,Zhang, Xiaoyi,Wang, Jun,Peng, Shiqi
experimental part, p. 4715 - 4723 (2009/06/17)
To find selective inhibitor of phosphodiesterase type 5 (PDE5), the essential structure elements of clinically used drugs sildenafil, vardenafil, and tadalafil were combined and a tetracyclic parent was constructed to which in 2-positions substituted acet
Toward breast cancer resistance protein (BCRP) inhibitors: design, synthesis of a series of new simplified fumitremorgin C analogues
Wu, Guofeng,Liu, Jiawang,Bi, Lanrong,Zhao, Ming,Wang, Chao,Baudy-Floc'h, Miche?le,Ju, Jingfang,Peng, Shiqi
, p. 5510 - 5528 (2008/02/07)
In this study, we report the design and synthesis of a series of new simplified fumitremorgin C analogues. The preliminary biological study indicated some of these simplified fumitremorgin C might be developed into breast cancer resistance inhibitors.
