1034296-25-7Relevant academic research and scientific papers
Methyl (11aS)-1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo- [3′,4′:1,2]pyridin[3,4-b]-indol-2-substituted acetates: Synthesis and three-dimensional quantitative structure-activity relationship investigation as a class of novel vasodilators
Liu, Jiawang,Zhao, Ming,Cui, Guohui,Zhang, Xiaoyi,Wang, Jun,Peng, Shiqi
experimental part, p. 4715 - 4723 (2009/06/17)
To find selective inhibitor of phosphodiesterase type 5 (PDE5), the essential structure elements of clinically used drugs sildenafil, vardenafil, and tadalafil were combined and a tetracyclic parent was constructed to which in 2-positions substituted acet
