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ALA-ALA-PRO-VAL-CMK is a synthetic peptide that acts as an irreversible and cell permeable inhibitor of human leukocyte elastase. It is composed of the amino acid sequence ALA-ALA-PRO-VAL, with a chloromethyl ketone (CMK) group attached to the C-terminus. The CMK group covalently bonds to the hydroxyl (OH) group of a serine residue or the thiol (SH) group of a cysteine residue on the target protein, thereby inhibiting its activity.

90105-47-8

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90105-47-8 Usage

Uses

Used in Pharmaceutical Industry:
ALA-ALA-PRO-VAL-CMK is used as a research tool for studying the role of human leukocyte elastase in various biological processes and diseases. It helps researchers understand the enzyme's function and its potential as a therapeutic target.
Used in Drug Development:
ALA-ALA-PRO-VAL-CMK is used as a lead compound in the development of new drugs targeting human leukocyte elastase. Its irreversible inhibition mechanism can be utilized to design more potent and selective inhibitors for the treatment of elastase-related disorders.
Used in Diagnostic Applications:
ALA-ALA-PRO-VAL-CMK can be used as a diagnostic agent to detect the presence and activity of human leukocyte elastase in biological samples. This can help in the early diagnosis and monitoring of elastase-related diseases.
Used in Enzyme Inhibition Studies:
ALA-ALA-PRO-VAL-CMK is used as an inhibitor in enzyme inhibition studies to investigate the kinetics and mechanism of human leukocyte elastase inhibition. This can provide valuable insights into the enzyme's structure and function, as well as the design of more effective inhibitors.

Check Digit Verification of cas no

The CAS Registry Mumber 90105-47-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,1,0 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 90105-47:
(7*9)+(6*0)+(5*1)+(4*0)+(3*5)+(2*4)+(1*7)=98
98 % 10 = 8
So 90105-47-8 is a valid CAS Registry Number.

90105-47-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name H-Ala-Ala-Pro-Val-chloromethylketone

1.2 Other means of identification

Product number -
Other names H-ALA-ALA-PRO-VAL-CMK

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:90105-47-8 SDS

90105-47-8Relevant academic research and scientific papers

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