90105-41-2 Usage
Uses
Used in Biochemical Research:
Z-L-Val-chloromethylketone is used as a research tool for studying the role of proteases in various biological processes. Its ability to irreversibly inhibit serine proteases makes it a valuable agent for dissecting the functions of these enzymes in different systems.
Used in Medical Research:
In the medical field, Z-L-Val-chloromethylketone is utilized as an investigative compound to understand the involvement of proteases in disease mechanisms, particularly those related to blood coagulation, fibrinolysis, and inflammatory responses. Its specificity allows researchers to explore potential therapeutic targets for conditions influenced by these processes.
Used in Drug Development:
Z-L-Val-chloromethylketone serves as a lead compound in the development of new drugs aimed at treating diseases where protease inhibition is beneficial. Its mechanism of action provides a foundation for designing more selective and effective therapeutic agents.
Used in Diagnostics:
Z-L-Val-chloromethylketone can be employed in diagnostic assays to detect the presence or activity of specific serine proteases, aiding in the identification of conditions where these enzymes are dysregulated.
Used in Pharmaceutical Industry:
Z-L-Val-chloromethylketone is used as a reference standard or control in the development and validation of assays for high-throughput screening of potential protease inhibitors, contributing to the advancement of new therapeutics.
Each application underscores the versatility and importance of Z-L-Val-chloromethylketone in the scientific and medical communities, where its unique properties facilitate a deeper understanding of protease functions and the development of targeted treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 90105-41-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,1,0 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 90105-41:
(7*9)+(6*0)+(5*1)+(4*0)+(3*5)+(2*4)+(1*1)=92
92 % 10 = 2
So 90105-41-2 is a valid CAS Registry Number.
90105-41-2Relevant academic research and scientific papers
PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF
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, (2015/07/07)
This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
PROCESS FOR THE PREPARATION OF ALPHA-CHLOROKETONES FROM ALKYL ESTERS
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Page/Page column 5, (2010/02/11)
The present invention relates to a process for the preparation of α-chloroketones from readily available alkyl esters by the reaction of a sulfoxonium ylide on said alkyl esters to generate a keto sulfoxonium ylide that is in turn treated with anhydrous HCl.
One-Carbon Chain Extension of Esters to α-Chloroketones: A Safer Route without Diazomethane
Wang, Dengjin,Schwinden, Mark D.,Radesca, Lilian,Patel, Bharat,Kronenthal, David,Huang, Ming-Hsing,Nugent, William A.
, p. 1629 - 1633 (2007/10/03)
The reaction of a variety of methyl esters with dimethylsulfoxonium methylide at 0-25 °C affords the chain-extended β-keto dimethylsulfoxonium ylides. Subsequent treatment with hydrogen chloride in THF proceeds with loss of DMSO to afford the corresponding α-chloroketones. This sequence has been utilized to convert the methyl esters of CBZ-protected alanine and valine to the anti N-protected α-amino epoxides, which are important pharmaceutical intermediates. When the same protocol is applied to BOC-protected phenylalanine methyl ester, epimerization occurs so that the use of a more reactive aryl ester is required. This chemistry provides a practical route to α-chloroketones that avoids the use of toxic and explosive diazomethane.
