901132-93-2

Upstream product

• 900807-30-9 Methanesulfonic acid (1R,4R,6R)-4,6-dihydroxy-1-[(S)-1-methyl-2-oxo-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-ethyl]-heptyl ester 
• 900807-29-6 (S)-3-[(2S,3R)-3-Hydroxy-2-methyl-5-((4R,6R)-2,2,6-trimethyl-[1,3]dioxan-4-yl)-pentanoyl]-4-phenyl-oxazolidin-2-one 
• 900807-31-0 (S)-3-{(S)-2-[(2S,5R)-5-((R)-2-Hydroxy-propyl)-tetrahydro-furan-2-yl]-propionyl}-4-phenyl-oxazolidin-2-one 
• 900807-23-0 1-{2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-propan-2-ol 
• 900807-26-3 tert-Butyl-dimethyl-[3-((4R,6R)-2,2,6-trimethyl-[1,3]dioxan-4-yl)-propoxy]-silane 
• 900807-25-2 (2R,4R)-7-(tert-Butyl-dimethyl-silanyloxy)-heptane-2,4-diol 
• 900807-24-1 1-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-heptan-4-one 
• 900807-27-4 3-((4R,6R)-2,2,6-Trimethyl-[1,3]dioxan-4-yl)-propan-1-ol 
• 900807-28-5 3-((4R,6R)-2,2,6-Trimethyl-[1,3]dioxan-4-yl)-propionaldehyde 
• 100-39-0 benzyl bromide 
• 16221-10-6 (+)-(2S,3S,6R,8R)-epi-Nonactic acid 

Downstream Products

• 900807-32-1 (S)-benzyl 2-((2S,5R)-5-((R)-2-((S)-2-((2S,5R)-5-((R)-2-(tert-butyldimethylsilyloxy)propyl)tetrahydrofuran-2-yl)propanoyloxy)propyl)tetrahydrofuran-2-yl)propanoate 

Relevant academic research and scientific papers

Alternating pattern of stereochemistry in the nonactin macrocycle is required for antibacterial activity and efficient ion binding

Nonactin is a polyketide antibiotic produced by Streptomyces griseus ETH A7796 and is an ionophore that is selective for K+ ions. It is a cyclic tetraester generated from two monomers of (+)-nonactic acid and two of (-)-nonactic acid, arranged

Synthesis of nonactin and the proposed structure of trilactone

An efficient enantioselective route to nonactin using a novel β-inversion of an Evans syn aldol to construct the THF ring is presented. Through total synthesis, the structure for trilactone proposed in the literature is shown likely to be incorrect.