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9012-63-9

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Cas No: 9012-63-9
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
Toxins, cholera
Cas No: 9012-63-9
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Toxins, cholera
Cas No: 9012-63-9
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CAS NO.9012-63-9 Toxins, cholera
Cas No: 9012-63-9
USD $ 50.0-100.0 / Gram 1 Gram 10000 Metric Ton/Month Wuhan Monad Medicine Tech Co.,LTD Contact Supplier
Toxins, cholera
Cas No: 9012-63-9
USD $ 100.0-100.0 / Kilogram 1 Kilogram 10000 Kilogram/Day Metric Ton/Day Zibo Hangyu Import&Export Co., Ltd Contact Supplier
9012-63-9 Toxins, cholera
Cas No: 9012-63-9
USD $ 30.0-40.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Cholera toxin
Cas No: 9012-63-9
No Data 10 Gram 1-100 Metric Ton/Month CHANGCHUN WEIERSI IMPORT AND EXPORT TRADE CO.,LTD Contact Supplier
Toxins, cholera
Cas No: 9012-63-9
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Toxins, cholera
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No Data No Data No Data Henan Tianfu Chemical Co., Ltd. Contact Supplier
Cholera toxin
Cas No: 9012-63-9
USD $ 1.0-2.0 / Gram 10 Gram 12 Kilogram/Day Hubei Jusheng Technology Co., Ltd., Contact Supplier

9012-63-9 Usage

Uses

Cholera Toxin from Vibrio cholerae has been used as a positive control in cAMP (cyclic AMP) assay for enterotoxins. It has been added as a supplement in cell culture media of primary tumors and epithelial cells.

Biochem/physiol Actions

Toxin consisting of an A subunit (27 kDa) surrounded by five B subunits (approximately 12 kDa each), which attach the toxin to ganglioside GM1 on the cell surface. The A subunit catalyzes ADP-ribosylation of the α-subunit of the stimulatory G protein (Gαs), reducing GTPase activity and activating the α-subunit. This activation of Gαs leads to an increase in the activity of adenylyl cyclase, resulting in increased levels of cAMP. Also ADP-ribosylates transducin in the eye rod outer segments, inactivating its GTPase activity. Cholera toxin has also been reported to ADP-ribosylate tubulin. Shown to be a potent mucosal vaccine adjuvant, inducing T helper cell type 2 responses by inhibiting the production of interleukin-12.
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