901245-65-6 Usage
Description
GSK 5959 exhibits >100-fold selectivity for BRPF1 (IC50 = 80 nM) over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3, which is involved in the epigenetic regulation of gene expression and have been implicated in human cancer.
Uses
GSK5959 is as elective BRPF1 bromodomain inhibitor.
Check Digit Verification of cas no
The CAS Registry Mumber 901245-65-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,1,2,4 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 901245-65:
(8*9)+(7*0)+(6*1)+(5*2)+(4*4)+(3*5)+(2*6)+(1*5)=136
136 % 10 = 6
So 901245-65-6 is a valid CAS Registry Number.
901245-65-6Relevant articles and documents
GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain
Bamborough, Paul,Barnett, Heather A.,Becher, Isabelle,Bird, Mark J.,Chung, Chun-Wa,Craggs, Peter D.,Demont, Emmanuel H.,Diallo, Hawa,Fallon, David J.,Gordon, Laurie J.,Grandi, Paola,Hobbs, Clare I.,Hooper-Greenhill, Edward,Jones, Emma J.,Law, Robert P.,Le Gall, Armelle,Lugo, David,Michon, Anne-Marie,Mitchell, Darren J.,Prinjha, Rab K.,Sheppard, Robert J.,Watson, Allan J. B.,Watson, Robert J.
supporting information, p. 552 - 557 (2016/07/06)
The BRPF (Bromodomain and PHD Finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. A selective benzimidazolone BRPF1 inhibitor showing micromolar activity in a cellular target engag
