878432-74-7Relevant academic research and scientific papers
GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain
Bamborough, Paul,Barnett, Heather A.,Becher, Isabelle,Bird, Mark J.,Chung, Chun-Wa,Craggs, Peter D.,Demont, Emmanuel H.,Diallo, Hawa,Fallon, David J.,Gordon, Laurie J.,Grandi, Paola,Hobbs, Clare I.,Hooper-Greenhill, Edward,Jones, Emma J.,Law, Robert P.,Le Gall, Armelle,Lugo, David,Michon, Anne-Marie,Mitchell, Darren J.,Prinjha, Rab K.,Sheppard, Robert J.,Watson, Allan J. B.,Watson, Robert J.
supporting information, p. 552 - 557 (2016/07/06)
The BRPF (Bromodomain and PHD Finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. A selective benzimidazolone BRPF1 inhibitor showing micromolar activity in a cellular target engag
1,3-dimethyl benzimidazolones are potent, selective inhibitors of the brpf1 bromodomain
Demont, Emmanuel H.,Bamborough, Paul,Chung, Chun-Wa,Craggs, Peter D.,Fallon, David,Gordon, Laurie J.,Grandi, Paola,Hobbs, Clare I.,Hussain, Jameed,Jones, Emma J.,Le Gall, Armelle,Michon, Anne-Marie,Mitchell, Darren J.,Prinjha, Rab K.,Roberts, Andy D.,Sheppard, Robert J.,Watson, Robert J.
supporting information, p. 1190 - 1195 (2015/04/27)
The BRPF (bromodomain and PHD finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. Here, we report the discovery, binding mode, and structure-activity relationship (SAR) of the firs
