901273-15-2

Basic information

• Product Name: N-(benzyloxycarbonyl)-β-(1-{4-[2',2'-bis(tert-butoxycarbonyl)vinyl]}naphthyl)-L-alanine
• Synonyms: N-(benzyloxycarbonyl)-β-(1-{4-[2',2'-bis(tert-butoxycarbonyl)vinyl]}naphthyl)-L-alanine
• CAS NO: 901273-15-2
• Molecular Weight: 575.659
• Mol File: 901273-15-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(benzyloxycarbonyl)-β-(1-{4-[2',2'-bis(tert-butoxycarbonyl)vinyl]}naphthyl)-L-alanine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(benzyloxycarbonyl)-β-(1-{4-[2',2'-bis(tert-butoxycarbonyl)vinyl]}naphthyl)-L-alanine(901273-15-2)
• EPA Substance Registry System: N-(benzyloxycarbonyl)-β-(1-{4-[2',2'-bis(tert-butoxycarbonyl)vinyl]}naphthyl)-L-alanine(901273-15-2)

Safety Data

• Hazardous Substances Data: 901273-15-2(Hazardous Substances Data)

Upstream product

• 901273-11-8 methyl N-(benzyloxycarbonyl)-β-(1-{4-[2',2'-bis(tert-butoxycarbonyl)]vinyl}naphthyl)-L-alaninate 
• 901273-00-5 1-[2',2'-bis(tert-butoxycarbonyl)vinyl]-4-methylnaphthalene 
• 901273-05-0 4-[2',2'-bis(tert-butoxycarbonyl)vinyl]naphthaldehyde 
• 901273-02-7 1-[2',2'-bis(tert-butoxycarbonyl)vinyl]-4-(bromomethyl)naphthalene 
• 901273-08-3 methyl (Z)-2-(benzyloxycarbonylamino)-3-{4-[2',2'-bis(tert-butoxycarbonyl)vinyl]}naphthylacrylate 
• 541-16-2 t-butyl malonate 
• 33738-48-6 4-methyl-1-naphthaldehyde 

Relevant articles and documents

An efficient and enantioselective synthesis of suitably protected β-[1-(4-malonyl)naphthyl]-L-alanine and β-[1-(4-malonylmethyl) naphthyl]-L-alanine: Novel fluorescent and non-hydrolysable phosphotyrosine mimetics

Molecular dynamics simulations based on the structure of the Grb7 SH2 domain in complex with the ErbB2 phosphorylated peptide pTyr1139 have suggested that β-[1-(4-malonyl)naphthyl]-L-alanine (L-mNal) may be accommodated in the pTyr binding pocket and offer additional beneficial interactions. Therefore, this compound and its analog β-[1-(4-malonylmethyl)naphthyl]-L-alanine (L-mmNal), which are new non-hydrolysable phosphotyrosine mimetics, have been prepared by the catalytic asymmetric hydrogenation of the corresponding prochiral enamides with excellent enantioselectivities. These compounds and their dehydro derivatives show interesting fluorescent properties. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.