901273-54-9

Basic information

• Product Name: N-(3-methoxyphenyl)-2-(methylamino)acetamide
• Synonyms: N-(3-methoxyphenyl)-2-(methylamino)acetamide
• CAS NO: 901273-54-9
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.23036
• Mol File: 901273-54-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-methoxyphenyl)-2-(methylamino)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-methoxyphenyl)-2-(methylamino)acetamide(901273-54-9)
• EPA Substance Registry System: N-(3-methoxyphenyl)-2-(methylamino)acetamide(901273-54-9)

Safety Data

• Hazardous Substances Data: 901273-54-9(Hazardous Substances Data)

Upstream product

• 536-90-3 m-Anisidine 
• 17641-08-6 2-chloro-N-(3-methoxyphenyl)acetamide 
• 74-89-5 methylamine 

Relevant articles and documents

Structure-Based Design, Synthesis, and Antifungal Activity of New Triazole Derivatives

A series of new antifungal triazole derivatives with phenylacetamide side chain were rational designed and synthesized on the basis of the structural information of lanosterol 14-demethylase (CYP51). In vitro antifungal activity assay indicated that several compounds showed higher activity than fluconazole. Especially, compound 8h showed excellent inhibitory activity against Candida albicans and Cryptococcus neoformans (MIC=0.0156μg/mL), suggesting that it is a promising lead for the development of novel antifungal agents. The binding mode of compound 8h was investigated by flexible molecular docking. It interacted with CACYP51 through hydrophobic and van der Waals interactions. A series of phenylacetamide-containing new azoles with good in vitro antifungal activity were rationally designed and synthesized.