90129-42-3

Usage

Uses

Used in Pharmaceutical Industry:
(S)-O-ISOPROPYLIDENE GLYCEROL MESYLATE is used as an intermediate for the synthesis of complex molecules, particularly in the creation of pharmaceuticals with biological activity. Its unique structure and reactivity contribute to the development of innovative drugs with potential therapeutic applications.
Used in Organic Chemistry:
(S)-O-ISOPROPYLIDENE GLYCEROL MESYLATE is used as a chiral building block in the field of organic chemistry. Its properties make it a valuable tool for the synthesis of enantiomerically pure compounds, which are essential in various chemical and pharmaceutical applications due to their specific interactions with biological targets.
Used in Synthesis of Complex Molecules:
(S)-O-ISOPROPYLIDENE GLYCEROL MESYLATE is used as a key component in the synthesis of complex molecules, taking advantage of its mesylate moiety as a good leaving group in substitution reactions. This feature allows for the efficient construction of intricate molecular structures with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C7H14O5S/c1-7(2)10-4-6(12-7)5-11-13(3,8)9/h6H,4-5H2,1-3H3/t6-/m0/s1

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 14347-78-5 1,2-O-isopropylidene-D-glycerol 
• 22323-82-6 (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol 

Downstream Products

• 248270-91-9 1-[(2S)-2,3-dihydroxy-2,3-isopropylidenepropoxy]-2-hydroxybenzene 
• 62703-32-6 (R)-3-(2-benzyloxyphenoxy)-1,2-propanediol acetonide 
• 753022-92-3 (S)-3-(3-benzyloxy-2-naphthoxy)-1,2-propanediol 
• 1010701-19-5 (R)-N-benzyl-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methanamine 
• 1416443-77-0 (R)-3-(2-benzyloxy-3-chlorophenoxy)-1,2-propanediol acetonide 
• 278783-81-6 (2S-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3-dioxolane-4-methanol methanesulfonate 
• 248270-95-3 1-[(2S)-2,3-dihydroxy-2,3-isopropylidenepropoxy]-2-[(2R)-2,3-epoxypropoxy]benzene 
• 753023-02-8 (S)-3-(3-benzyloxy-5,6,7,8-tetrahydro-2-naphthoxy)-1,2-propanediol 

Relevant academic research and scientific papers

1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS

Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.

2-OXO-THIAZOLE DERIVATIVES AS A2A INHIBITORS AND COMPOUNDS FOR USE IN THE TREATMENT OF CANCERS

The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. The invention further relates to the use of the compounds of Formula (I) as A2A inhibitors. The invention also relates to the use of the compounds of Formula (I) for the treatment and/or prevention of cancer. The invention also relates to a process for manufacturing compounds of Formula (I).

Metabolism of 2,3-dihydroxypropane-1-sulfonate by marine bacteria

Both enantiomers of the sulfoquinovose breakdown product 2,3-dihydroxypropane-1-sulfonate, an important sulfur metabolite produced by marine algae, were synthesised in a 34S-labelled form and used in feeding experiments with marine bacteria. The labelling was efficiently incorporated into the sulfur-containing antibiotic tropodithietic acid and sulfur volatiles by the algal symbiont Phaeobacter inhibens, but not into sulfur volatiles released by marine bacteria associated with crustaceans. The ecological implications and the relevance of these findings for the global sulfur cycle are discussed.

ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS

The disclosure provides compounds and pharmaceutical compositions of aryloxyacetylindoles compounds and analogs useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds of general Formula (I) (I) or a pharmaceutically acceptable salt or prodrug thereof. Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a subject, including Pseudomonas aeruginosa infections, are also provided by the disclosure.

N-ACYLPIPERIDINE ETHER TROPOMYOSIN-RELATED KINASE INHIBITORS

The present invention relates to compounds of Formula (I) described herein and their pharmaceutically acceptable salts, and their use in medicine, in particular as Trk antagonists.

ANTIVIRAL COMPOUNDS AND COMPOSITIONS

Described herein are compounds useful in the treatment of viral diseases, compositions comprising them and methods of using them. The compounds comprise a nucleoside or nucleoside analog linked, commonly through a phosphate group to one of a selected grou

ACYCLIC AMINE INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND HYDROLASES

The invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNPs) and/or nucleoside hydrolases (NHs). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

3-CYCLOALKYLCARBONYL INDOLES AS CANNABINOID RECEPTOR LIGANDS

The present invention provides novel compounds of Formula (I), which are CB2 selective ligands useful for the treatment of pain.

Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: Structure-activity relationships and receptor docking

The activation of P2Y1 receptors in platelets contributes to platelet aggregation, and selective antagonists are sought as potential antithrombotic agents. We reported (Kim et al. J. Med. Chem. 2000, 43, 746-755) that acyclic analogues of adeni

Stereocontrolled Synthesis of Key Advanced Intermediates toward Simplified Acetogenin Analogues

The stereo- and enantiocontrolled synthesis of substituted β-hydroxy ethers based on glycol and catechol bearing an alkyne group and a series of substituents is reported. These substrates were designed to mimic the bis-THF array of annonaceous acetogenins and to provide an access to simplified and modified analogues. The key steps of the synthesis involve the condensation of the nonracemic mesylate of solketal with ethylene glycol and catechol, followed by an alkylation with a glycidyl derivative. Under appropriate conditions, the reaction is completely stereoselective and allows the synthesis of all the diastereomers. After the epoxide was opened with triethylsilylacetylene, the second epoxide was unmasked and reacted with a series of alkyl, aryl, amine, and alcohol reagents. A series of 28 analogues was prepared having a glycol or a catechol core, a stereodefined configuration of the flanking hydroxyl groups, and an acetylenic appendage suitable for a coupling to a lactone-bearing fragment.