90129-42-3

Basic information

• Product Name: (S)-O-ISOPROPYLIDENE GLYCEROL MESYLATE
• Synonyms: 1,3-DIOXOLANE-4-METHANOL, 2,2-DIMETHYL-, METHANESULFONATE, (4S)-;(S)-O-ISOPROPYLIDENE GLYCEROL MESYLATE;(S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol methanesulfonate
• CAS NO: 90129-42-3
• Molecular Formula: C₇H₁₄O₅S
• Molecular Weight: 210.25
• Mol File: 90129-42-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 322.4°C at 760 mmHg
• Flash Point: 148.8°C
• Appearance: /
• Density: 1.207g/cm³
• Vapor Pressure: 0.000528mmHg at 25°C
• Refractive Index: 1.445
• CAS DataBase Reference: (S)-O-ISOPROPYLIDENE GLYCEROL MESYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-O-ISOPROPYLIDENE GLYCEROL MESYLATE(90129-42-3)
• EPA Substance Registry System: (S)-O-ISOPROPYLIDENE GLYCEROL MESYLATE(90129-42-3)

Safety Data

• Hazardous Substances Data: 90129-42-3(Hazardous Substances Data)

Usage

General Description

(S)-O-Isopropylidene glycerol mesylate is a chemical compound used in organic synthesis. It is an intermediate in the preparation of various pharmaceuticals and organic compounds. The mesylate moiety acts as a good leaving group in substitution reactions, making it a useful compound for the synthesis of complex molecules. This chemical is commonly used in the preparation of chiral building blocks and in the creation of pharmaceuticals with biological activity. Its unique structure and reactivity make it a valuable tool in the field of organic chemistry.

InChI:InChI=1/C7H14O5S/c1-7(2)10-4-6(12-7)5-11-13(3,8)9/h6H,4-5H2,1-3H3/t6-/m0/s1

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 14347-78-5 1,2-O-isopropylidene-D-glycerol 
• 22323-82-6 (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol 

Downstream Products

• 248270-91-9 1-[(2S)-2,3-dihydroxy-2,3-isopropylidenepropoxy]-2-hydroxybenzene 
• 62703-32-6 (R)-3-(2-benzyloxyphenoxy)-1,2-propanediol acetonide 
• 1010701-19-5 (R)-N-benzyl-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methanamine 
• 1416443-77-0 (R)-3-(2-benzyloxy-3-chlorophenoxy)-1,2-propanediol acetonide 
• 278783-81-6 (2S-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3-dioxolane-4-methanol methanesulfonate 
• 248270-95-3 1-[(2S)-2,3-dihydroxy-2,3-isopropylidenepropoxy]-2-[(2R)-2,3-epoxypropoxy]benzene 
• 753023-02-8 (S)-3-(3-benzyloxy-5,6,7,8-tetrahydro-2-naphthoxy)-1,2-propanediol 
• 753022-92-3 (S)-3-(3-benzyloxy-2-naphthoxy)-1,2-propanediol 

Relevant articles and documents

1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS

Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.

Metabolism of 2,3-dihydroxypropane-1-sulfonate by marine bacteria

Both enantiomers of the sulfoquinovose breakdown product 2,3-dihydroxypropane-1-sulfonate, an important sulfur metabolite produced by marine algae, were synthesised in a 34S-labelled form and used in feeding experiments with marine bacteria. The labelling was efficiently incorporated into the sulfur-containing antibiotic tropodithietic acid and sulfur volatiles by the algal symbiont Phaeobacter inhibens, but not into sulfur volatiles released by marine bacteria associated with crustaceans. The ecological implications and the relevance of these findings for the global sulfur cycle are discussed.

N-ACYLPIPERIDINE ETHER TROPOMYOSIN-RELATED KINASE INHIBITORS

The present invention relates to compounds of Formula (I) described herein and their pharmaceutically acceptable salts, and their use in medicine, in particular as Trk antagonists.