901311-75-9Relevant academic research and scientific papers
Microwave-assisted, efficient and regioselective Pd-catalyzed C-phenylation of halopyrimidines
Ceide, Susana Conde,Montalban, Antonio Garrido
, p. 4415 - 4418 (2007/10/03)
We herein report that flash heating microwave irradiation is a helpful tool in the formation of arylpyrimidines from the corresponding halopyrimidines. The palladium-catalyzed cross-coupling reactions of 2,4-di- and 2,4,5-trihalopyrimidines with phenylboronic acid under the above conditions are described. By use of the appropriate catalyst and the adequate halopyrimidine, good regioselectivity can be achieved in the 2-, 4-, or 5-positions of the heterocycle. In addition, we show that this methodology is ameneable for the stepwise preparation of mono-, di-, and triphenylpyrimidines.
3-AMINO-2-HYDROXYPROPYL OF PYRIMIDIN-4-ONE USEFUL AS ANTIHYPERTENSIVE, CARDIOSELECTIVE, ANTIARRHYTHMIC, AND ANTIANGINAL AGENTS
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, (2008/06/13)
The novel compounds of this invention and their pharmaceutically acceptable salts exhibit cardioselective β-adrenergic blocking activity, with a direct relaxing effect on the β. sub.2-adrenergic receptors and are useful as antihypertensive, cardioprotecti
