90146-65-9Relevant academic research and scientific papers
Electrochemical synthesis of 1,2,4-triazole-fused heterocycles
Ye, Zenghui,Ding, Mingruo,Wu, Yanqi,Li, Yong,Hua, Wenkai,Zhang, Fengzhi
supporting information, p. 1732 - 1737 (2018/04/30)
A reagent-free intramolecular dehydrogenative C-N cross-coupling reaction has been developed under mild electrolytic conditions. In this atom- and step-economical one-pot process, valuable 1,2,4-triazolo[4,3-a]pyridines and related heterocyclic compounds could be synthesized efficiently from commercially available aliphatic or (hetero)aromatic aldehydes and 2-hydrazinopyridines. Various functional groups are compatible with this metal- and oxidant-free protocol which can be carried out on a gram scale easily. This novel method was applied to the synthesis of one of the top-selling drugs Xanax and late stage functionalization for generating chemical diversity in biologically relevant lead molecules.
Thallium(III) salts in heterocyclic synthesis: Synthesis of 3-aryl-9-methyl-1, 2, 4-triazolo[4, 3-α]quinolines
Singh,Muthukrishnan,Sundaravadivelu
, p. 262 - 265 (2007/10/03)
Oxidation of arenecarbaldebyde 4-methylquinolin-2-ylhydrazones 2a-h with thallium(Ill) acetate in acetic acid, thallium(III) acetate and thallium(III) nitrate in acetonitrile or methanol in the presence of perchloric acid, p-toluene sulphonic acid etc. af
Microwave assisted synthesis and pharmacological screening of 3-(substituted phenyl)-5-methylquinolino-1,2,4-triazines
Kidwai, Mazaahir,Kohli, Seema,Goel, A. K.,Dubey, M. P.
, p. 1063 - 1065 (2007/10/03)
A series of quinolinotriazines have been synthesized by condensation of 2-hydrazino-4-methylquinoline 3 with aromatic aldehydes followed by nitrosation with sodium nitrite in acetic acid leading to ring closure under microwave irradiation.
Microwave assisted synthesis and antifungal activity of 1,2,4-triazine, 1,2,4-triazole, tetrazole and pyrazole derivatives
Kidwai, Mazaahir,Goel, Yogesh,Kumar, Rajesh
, p. 174 - 179 (2007/10/03)
The condensation reactions of 2-hydrazino-4-methylquinoline with diethyl oxalate, ethyl bromoacetate, aromatic aldehydes, acetic anhydride, nitrous acid and different acetophenones followed by DMF and POCl3 under microwave irradiation and by conventional methods are described. The reaction rate is enhanced tremendously under microwave irradiation as compared to conventional method with improved yields. All the newly synthesised compounds have been screened for antifungal activity against fungi A. niger andA.flavous.
