90154-71-5Relevant academic research and scientific papers
METHOD FOR PRODUCING NITRILE COMPOUND
-
Paragraph 0041-0044; 0048; 0051, (2016/11/17)
PROBLEM TO BE SOLVED: To provide a method for producing a nitrile compound capable of obtaining a nitrile compound in a short time and at a low temperature, while maintaining a high yield. SOLUTION: There is provided a method for producing a nitrile compound using a compound having a hydroxymethylene group as a raw material. The nitrile compound is obtained by mixing and reacting an aliphatic compound or an aromatic compound having a hydroxymethylene group with a N-nitrosyl compound, an oxidant, an iodinating agent and ammonia water. COPYRIGHT: (C)2015,JPO&INPIT
Cyclohexylcarbonitriles: Diastereoselective arylations with TMPZnCl·LiCl
Mycka, Robert J.,Duez, Stephanie,Bernhardt, Sebastian,Heppekausen, Johannes,Knochel, Paul,Fleming, Fraser F.
, p. 7671 - 7676 (2012/10/30)
Deprotonating substituted cyclohexanecarbonitriles with TMPZnCl·LiCl affords zincated nitriles that diastereoselectively couple with aryl bromides in the presence of catalytic Pd(OAc)2 and S-Phos. Steric and electronic effects influence the dia
