90172-66-0

Usage

Molecular weight

267.26 g/mol

Structure

A derivative of indole with a fluorobenzoyl group attached to the 1-position

Usage

Used in the synthesis of various pharmaceuticals and agrochemicals
Commonly used as a building block in organic synthesis to produce a variety of biologically active molecules
Versatile reactivity and ability to undergo various chemical transformations
Value as an intermediate in the production of pharmaceuticals and other compounds with biological activity
Studied for potential applications in the design and development of new drugs and agrochemicals

Upstream product

• 120-72-9 indole 
• 403-43-0 4-fluorobenzoyl chloride 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 824-75-9 p-fluorobenzamide 
• 352-34-1 4-fluoro-1-iodobenzene 
• 201230-82-2 carbon monoxide 

Relevant academic research and scientific papers

Highly efficient aminocarbonylation of iodoarenes at atmospheric pressure catalyzed by a robust acenaphthoimidazolyidene allylic palladium complex

A robust allylic palladium-NHC complex was developed and exhibited extremely high catalytic activity toward aminocarbonylation of various (hetero)aryl iodides under atmospheric carbon monoxide pressure, in which a broad range of secondary and primary amines were well tolerated. In addition, the concise synthesis of an anticancer drug tamibarotene was accomplished even in a gram scale, further highlighting the practical applicability of the protocol.

A novel one-pot synthesis of N-acylindoles from primary aromatic amides

A novel one-pot synthesis of N-acylindoles via tandem cycloalkylation- annelation is described. This approach is based on the use of a strong solid-acid catalyst, montmorillonite K-10, and microwave irradiation under solvent-free conditions. The tandem cy

p-Fluorobenzoyl Chloride for Characterization of Active Hydrogen Functional Groups by Fluorine-19 Nuclear Magnetic Resonance Spectrometry

The base-catalyzed reactions of p-fluorobenzoyl chloride provide a convenient method for (19)F NMR analysis of alcohols, phenols, carboxylic acids, amines, and thiols.The (19)F chemical shift and yield data for p-fluorobenzoyl derivatives for nearly 100 compounds are presented.The yield data for these p-fluorobenzoyl derivatives suggest a simple, and in many cases, quantitative method for introducing a fluorine tagging group.The (19)F chemical shifts indicate a wide chemical shift range (ca. 10 ppm) for a large number of compounds.Furthermore, most chemical classes (e.g., phenols, alcohols, etc.) have fairly well resolved chemical shift regions.