90175-99-8Relevant academic research and scientific papers
BICYCLIC HETEROCYCLIC COMPOUNDS AS PDE2 INHIBITORS
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, (2017/01/23)
The present invention is directed to dihydropyrazolopyrimidinone compounds of formulas (I) and (II) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
Bicyclic Heterocycles with Nitrogen at the Ring Junction. Part 2. Application of the Dakin-West Reaction to the Synthesis of Imidazo-1,2,4-triazin-4(3H)-ones
Charles, Isabel,Latham, David W. S.,Hartley, David,Oxford, Alexander W.,Scopes, David I. C.
, p. 1139 - 1146 (2007/10/02)
A series of novel acylamino α-keto-esters (4) have been prepared via a Dakin-West reaction of acylated α-amino-acids and ethyl oxalyl chloride.Their use in a general synthesis of imidazo-1,2,4-triazin-4(3H)-ones (7) is described.The conversion of t
