90176-39-9

Upstream product

• 14131-63-6 D-glucosamine hydrochloride 
• 100-52-7 benzaldehyde 
• 1078691-95-8 (+)-D-glucosamine hydrochloride 

Downstream Products

• 85065-26-5 4,6-O-benzylidene-2-benzylideneamino-2-deoxy-β-D-glucopyranose 
• 85065-32-3 2-<(3R)-3-acetoxytetradecanamido>-3,6-di-O-acetyl-2-deoxy-4-O-diphenylphosphono-α-D-glucopyranosyl bromide 
• 85071-05-2 2-<(3R)-3-acetoxytetradecanamido>-1,3,6-tri-O-acetyl-2-deoxy-β-D-glucopyranose 4-diphenylphosphate 
• 85065-33-4 2-<(3R)-3-acetoxytetradecanamido>-6-O-<2-<(3R)-3-acetoxatetradecanamido>-3,6-di-O-acetyl-2-deoxy-4-O-diphenylphosphono-β-D-glucopyranosyl>-1,3-di-O-acetyl-2-deoxy-β-D-glucopyranose 
• 85065-27-6 1,3-di-O-acetyl-4,6-O-benzylidene-2-benzylideneamino-2-deoxy-β-D-glucopyranose 
• 85065-29-8 2-<(3R)-3-acetoxytetradecanamido>-1,3-di-O-acetyl-4,6-O-benzylidene-2-deoxy-β-D-glucopyranose 
• 85065-28-7 1,3-di-O-acetyl-2-amino-4,6-O-benzylidene-2-deoxy-β-D-glucopyranose hydrochloride 
• 5432-46-2 acetyl 3,4,6-tri-O-acetyl-2-amino-2-deoxy-D-glucopyranoside hydrochloride 
• 122210-05-3 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranose 
• 144923-61-5 N-benzyloxycarbonyl-O-<3,4,6-tri-O-acetyl-2-(N-2,2,2-trichloroethyloxycarbonyl)-amino-2-deoxy-β-D-glucopyranosyl>threonine tert-butyl ester 
• 144944-17-2 N-benzyloxycarbonyl-O-<3,4,6-tri-O-acetyl-2-N-(2,2,2-trichloroethyloxycarbonyl)-amino-2-deoxy-β-D-glucopyranosyl>-serine tert-butyl ester 
• 144923-60-4 N-benzyloxycarbonyl-O-<3,4,6-tri-O-acetyl-2-(N-2,2,2-trichloroethyloxycarbonyl)-amino-2-deoxy-β-D-glucopyranosyl>-seryl-alanine tert-butyl ester 
• 17460-45-6 tetra-acetyl glucosamine 
• 56644-75-8 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(2,2,2-trichloroacetamido)-β-D-glucopyranose 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of novel flavone Mannich base derivatives as potential antibacterial agents

Abstract: A series of novel Mannich base derivatives of flavone containing benzylamine moiety was synthesized using the Mannich reaction. The results of antifungal activity are not ideal, but its antifungal effect has a certain increase compared to flavonoids. After that, four bacteria were used to test antibacterial experiments of these compounds; compound 5g (MIC = 0.5, 0.125?mg/L) showed significant inhibitory activity against Staphylococcus aureus and Salmonella gallinarum compared with novobiocin (MIC = 2, 0.25?mg/L). Compound 5s exhibited broad spectrum antibacterial activity (MIC = 1, 0.5, 2, 0.05?mg/L) against four bacteria. The selected compounds 5g and 5s exhibit potent inhibition against Topo II and Topo IV with IC50 values (0.25–16?mg/L). Molecular docking model showed that the compounds 5g and 5s can bind well to the target by interacting with amino acid residues. It will provide some valuable information for the commercial antibacterial agents. Graphical Abstract: [Figure not available: see fulltext.].

Glucosamide compound and preparation and application thereof

The invention relates to a glucosamide compound and a preparation method thereof. The glucosamide compound has a structure as shown in the formula (I). In the formula (I), R is methoxy group, nitro group, amino-group, hydroxyl group, C1-4 alkyl group or halogen, n is the number of substituent groups, and n is 1 or 2. The glucosamide compound is simple to prepare, has excellent plant induced resistance activity, and can be used as a plant induced resistance agent for controlling cucumber bacterial angular leaf spot, cucumber target leaf spot and tomato late blight. The invention also relates to a plant induced resistant agent containing the compound.

Prednisolone succinate-glucosamine conjugate: Synthesis, characterization and in vitro cellular uptake by kidney cell lines

Prednisolone succinate-glucosamine (PSG) conjugate, a prodrug for prednisolone, was synthesized and confirmed by NMR and MS spectrum. The stabilities of the prodrug in PBS (pH 2.50, 5.00, 7.20, and 7.89) were studied. Cytotoxicity and uptake assay of the prodrug were perfomed on HK-2 and MDCK cell lines. The results showed that compared with prednisolone, the PSG not only did not increase the cytotoxicity but also improved the uptake to 2.2 times of prednisolone by the cells. Thus, it indicated that glucosamine might be a potential carrier for kidney-targeting delivery of prednisolone.

A carbohydrate-linked hypericinic photosensitizing agent

With respect to an enhanced solubility under physiological conditions, a carbohydrate-containing hypericin-based second-generation photosensitizer was prepared. Its photochemical properties were tested by means of the light-sensitized destruction of bilir