90192-47-5Relevant academic research and scientific papers
Synthetic method of (S)-N'-(2-benzyloxy propylidene)formhydrazide
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Paragraph 0034-0035; 0041-0042; 0046-0047, (2019/05/08)
Disclosed is a synthetic method of (S)-N'-(2-benzyloxy propylidene)formhydrazide. The method includes the following steps: firstly, (S)-2-benzyloxy propionic acid with an acylation reagent to obtain (S)-2-benzyloxy propionyl chloride; and adding a palladi
A (S)-2 - benzyloxy propionaldehyde synthetic method (by machine translation)
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Paragraph 0029; 0030; 0035; 0036; 0039; 0040, (2019/05/08)
A (S)- 2 - benzyloxy-propionic aldehyde synthesis method, the method for synthesis of the specific step includes: (1) the first (S)- 2 - animal pen oxygen radical propionic acid with an acylating reagent reaction, to obtain (S)- 2 - [...]; (2) then the pa
Method for synthesizing N'-[(2S, 3S)-2-(benzyloxy) pentyl-3-base] formylhydrazine
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Paragraph 0039; 0040; 0048; 0049; 0055; 0056, (2019/06/27)
A method for synthesizing N'-[(2S, 3S)-2-(benzyloxy) pentyl-3-base] formylhydrazine comprises the following steps: reacting (S)-2-benzyloxypropionic acid with an acylation reagent to obtain (S)-2-benzyloxy propionyl chloride; adding a palladium barium sulfate catalyst into o-xylene and reacting in hydrogen atmosphere for 15-30 min; adding (S)-2-benzyloxy propionyl chloride hydrogen atmosphere forreflux reaction until hydrogen is not absorbed; after the reaction is finished, the catalyst is filtered and the o-xylene is removed to obtain (S)-2-benzyloxypropionaldehyde; reacting the (S)-2-benzyloxypropionaldehyde with formylhydrazine, removing the solvent after finishing the reaction, and post-treating to obtain (S)-N'-(2 benzyloxypropyl) formylhydrazine; reacting the (S)-N'-(2 benzyloxypropyl) formylhydrazine with a Grignard reagent, and post-treating to obtain N'-((2s,3s)- 2-(benzyloxy) pentyl-3-base] formylhydrazine. According to the invention, an acylating reagent which is low in price and safer and more environment-friendly in reaction and a palladium barium sulfate catalyst which can be recycled for a plurality of times are used as reaction raw materials, so that the reaction process more conforms to the principle of atom economy, and the reaction is milder.
Cerium(III) chloride-mediated vinylation of acylsilanes: A convenient new entry to silylated allylic alcohols
Bonini,Comes-Franchini,Fochi,Mazzanti,Ricci,Varchi
, p. 1688 - 1690 (2007/10/03)
The reaction of alkyl, cycloalkyl, aromatic, heteroaromatic and α,β-unsaturated acylsilanes 1-7 and of homochiral acylsilanes 15 and 16 with the complex vinylmagnesium bromide/CeCl3 affords the silylated allylic alcohols in satisfactory to exce
Useful for treating neurodegenerative diseases
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, (2008/06/13)
Novel benzomorphan derivatives of the formula STR1 wherein R1 -R8 are as defined herein. The benzomorphan derivatives are useful for treating cerebral ischaemia of various origins, epilepsy and neurodegenerative diseases.
