90195-18-9Relevant academic research and scientific papers
Synthesis and Binding Studies of Crown Ethers Bearing Pharmacophoric Groups: Epoxy Lariat Crown Ethers
Jarvis, Bruce B.,Vrudhula, Vivekananda M.,Dishong, Dennis M.,Gokel, George W.
, p. 2423 - 2427 (2007/10/02)
A series of lariat ethers (derivatives of 18-crown-6, 15-crown-5, and 12-crown-4) bearing pendant epoxy groups has been prepared and the homogeneous stability (binding) constants (Ks) with Na+ and K+ in MeOH have been measured.The epoxy groups appear to have only a marginal influence on complexation of K+ in the larger ring compounds and do not enhance Na+ binding.These epoxy lariat ethers exhibit no in vivo activity against P388 mouse leukemia at dose levels of 128 mg/kg and below.
