16479-39-3

Upstream product

• 120-80-9 benzene-1,2-diol 

Downstream Products

• 90195-20-3 <<2-(2'-methyl-2-propenyloxy)phenoxy>methyl>-18-crown-6 
• 344742-10-5 2-[2-(2-Methyl-oxiranylmethoxy)-phenoxymethyl]-1,4,7,10,13,16-hexaoxa-cyclooctadecane 
• 90195-19-0 <<2-(methallyloxy)phenoxy>methyl>-15-crown-5 
• 344583-88-6 2-[2-(2-Methyl-oxiranylmethoxy)-phenoxymethyl]-1,4,7,10,13-pentaoxa-cyclopentadecane 
• 90195-18-9 <<2-(methallyloxy)phenoxy>methyl>-12-crown-4 
• 344568-59-8 2-[2-(2-Methyl-oxiranylmethoxy)-phenoxymethyl]-1,4,7,10-tetraoxa-cyclododecane 
• 90195-16-7 3--1,2-propanediol 

Relevant academic research and scientific papers

Synthesis and Binding Studies of Crown Ethers Bearing Pharmacophoric Groups: Epoxy Lariat Crown Ethers

A series of lariat ethers (derivatives of 18-crown-6, 15-crown-5, and 12-crown-4) bearing pendant epoxy groups has been prepared and the homogeneous stability (binding) constants (Ks) with Na+ and K+ in MeOH have been measured.The epoxy groups appear to have only a marginal influence on complexation of K+ in the larger ring compounds and do not enhance Na+ binding.These epoxy lariat ethers exhibit no in vivo activity against P388 mouse leukemia at dose levels of 128 mg/kg and below.