90200-01-4

Upstream product

• 92016-16-5 2-Hydroxy-cyclohexanon-⁽¹⁾-essigsaeure-⁽²⁾-aethylester 
• 24731-17-7 ethyl 2-(2-oxocyclohexyl)acetate 
• 29941-87-5 isobutyl enol ether of cyclohexane-1,2-dione 
• 108-94-1 cyclohexanone 
• 947695-84-3 benzyl 2-(1-hydroxycyclohexyl)acetate 
• 947695-87-6 benzyl 2-(1-hydroxy-2-oxocyclohexyl)acetate 

Downstream Products

• 90534-64-8 methyl 2-(6-oxocyclohex-1-en-1-yl)acetate 
• 1438-96-6 (2-oxocyclohexyl)acetic acid 
• 75032-20-1 (1-Hydroxy-2-oxocyclohexyl)essigsaeure-methylester 

Relevant academic research and scientific papers

Scalable preparation of both enantiomers of 2-(1-hydroxy-2-oxocyclohexyl) acetic acid

(Chemical Equation Presented) The efficient, scalable preparation of both enantiomers of 2-(1-hydroxy-2-oxocyclohexyl)acetic acid in enantiomerically pure form is reported using environmentally benign conditions in 30% overall yield (6 steps) for the (S)-isomer, in 27% (7 steps) for the (R)-isomer, from cyclohexanone.

Synthesis of bicyclic pyroglutamic acid featuring the ugi reaction and a unique stereoisomerization at the angular position by Grob fragmentation followed by a transannular ketene [2+2] cycloaddition reaction

A stereoisomerization at the angular position of N-acylindoles during basic hydrolysis was discovered to give only the syn-bicyclic pyroglutamic acid, proceeding through a transannular [2+2] cycloaddition of a ketene-ketone intermediate generated by a Gro