90210-23-4

Upstream product

• 775558-75-3 Acetic acid 4-(4-isopropyl-piperazine-1-carbonyl)-phenyl ester 
• 4318-42-7 1-(1-methylethyl)piperazine 
• 2345-34-8 4-acetyloxy-benzoic acid 
• 27914-73-4 4-acetoxybenzoyl chloride 

Relevant academic research and scientific papers

SUBSTITUTED PHENYL PROPYL AMINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS

Certain substituted phenyl propyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.

Synthesis of 4-(4-guanidinobenzoyloxy)benzamides and 1-(4-guanidinobenzoyloxy)benzoyloxy acetamides as trypsin inhibitors

Seventeen new compounds of 4-(4-guanidinobenzoyloxy)benzamides and 4-(4-guanidinobenzoyloxy)benzoyloxyacetamides were prepared and their inhibitory activities on trypsin, thrombin and porcine pancreatic elastase were measured. These compounds were found to be selective trypsin inhibitors with inhibiting activities from 0.44 to 43 μM.

Synthesis of 1-(4-acyloxybenzoyloxyacetyl)-4-alkylpiperazines and 1-(4-acyloxybenzoyl)-4-alkylpiperazines as inhibitors of chymotrypsin

Sixteen new esters and amides of 4-acyloxybenzoic acids were prepared and screened as chymotrypsin inhibitors. Inhibiting activities on chymotrypsin differed markedly (>100-0.008 μM). Compounds which contained the 4-benzoyloxyacetyl moiety showed considerably higher activity then dacyloxybenzamides. Compounds 1c and 11f are also weak trypsin inhibitors.