90210-47-2Relevant academic research and scientific papers
Studies on organophosphorus compounds XLVII: Acetyl chloride - A versatile reagent for the synthesis of 1-aminoalkyl- and amino(aryl)methylphosphonic acid derivatives
Yuan,Chen,Wang
, p. 490 - 493 (2007/10/02)
Acetyl chloride is used successfully in the synthesis of 1-aminoalkyl- and amino(aryl)methylphosphonic acid derivatives by a three-component condensation reaction involving diethyl phosphoramidate, aldehydes and diphenyl phosphite. Furthermore, in the reaction of benzyl carbamate, aldehydes and phosphorus(III) chloride, acetyl chloride facilates the formation of alkyl hydrogen 1-(benzyloxycahronylamino)alkylphosphonates or aryl(benzyloxycarbonylamino)methylphosphonates, key intermediates in the synthesis of phosphonopeptide with a P-N bond. In comparison with other methods, the present variation affords wider scope of application including the use of some aliphatic aldehydes, fair yields and mild reaction conditions.
AMINOPHOSPHONIC ACIDS. PART XVII. SYNTHESES AND PROPERTIES OF N-ACYL-1-AMINOALKANEPHOSPHONIC ACID 2-CYANOETHYL ESTERS
Szewczyk, Jerzy,Rachon, Janusz,Wasielewski, Czeslaw
, p. 477 - 483 (2007/10/02)
2-cyanoethyl monoesters and non-symmetrical 2-cyanoethyl-methyl diesters of N-acyl-1-amino-alkanephosphonic acid were prepared.Properties of 2-cyanoethyl esters as protecting groups of a phosphonic group were examined.
