90212-03-6

Usage

InChI:InChI=1/C20H28O2S/c1-19-9-8-17-15(16(19)5-6-18(19)22)4-3-13-11-14(21)7-10-20(13,17)12-23-2/h11,15-17H,3-10,12H2,1-2H3/t15-,16-,17-,19-,20+/m0/s1

Upstream product

• 90212-07-0 (3S,8S,9S,10S,13S,14S)-3-Hydroxy-13-methyl-10-methylsulfanylmethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-17-one 
• 82341-96-6 3β-Hydroxy-19-iodo-5-androsten-17-one acetate 
• 82353-12-6 Acetic acid (3S,8S,9S,10S,13S,14S)-10-methanesulfonylsulfanylmethyl-13-methyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 90212-01-4 (3S,8S,9S,10S,13S,14S)-3-Hydroxy-10-mercaptomethyl-13-methyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-17-one 

Relevant academic research and scientific papers

Steroidal C-19 Sulphur and Nitrogen Derivatives designed as Aromatase Inhibitors

The discovery that in the steroidal compounds (6) and (15) iodine in the 19-position is smoothly displaced by reactive nucleophiles (CN(1-), MeSO2S(1-), N3(1-)) without rearrangement was exploited in the synthesis of 19-methylthio-4-androstene-3,17-dione (14) which was shown to inhibit aromatase by co-ordination of the steroidal sulphur atom to the haem-iron of cytochrome P-450.