Journal of the Chemical Society. Chemical communications p. 1733 - 1735 (1985)
Update date:2022-08-03
Topics:
Wright, J. Neville
Calder, Michael R.
Akhtar, Muhammad
The discovery that in the steroidal compounds (6) and (15) iodine in the 19-position is smoothly displaced by reactive nucleophiles (CN(1-), MeSO2S(1-), N3(1-)) without rearrangement was exploited in the synthesis of 19-methylthio-4-androstene-3,17-dione (14) which was shown to inhibit aromatase by co-ordination of the steroidal sulphur atom to the haem-iron of cytochrome P-450.
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