90213-39-1Relevant academic research and scientific papers
SYNTHESIS OF 3-SUBSTITUTED 4-METHYLMERCAPTO- AND 4-AMINOPYRAZOLOPYRIMIDINES AND THEIR RIBOSIDES
Bulychev, Yu. N.,Korbukh, I. A.,Preobrazhenskaya, M. N.
, p. 210 - 215 (2007/10/02)
3-Cyano-4-methylmercaptopyrazolopyrimidine, fusion of which with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose gave its per-O-acetylated 1-β-D-ribofuranoside in 61percent yield, was synthesized from 3,4-dicyano-5-aminopyrazole.O-Deacetylation of the per-O-acetylated 1-β-D-ribofuranoside was carried out by the action of 1percent HCl in methanol. New pyrazolopyrimidines were obtained by the reaction of 3-cyano-4-methylmercaptopyrazolopyrimidine and its 1-riboside, as well as 3-cyano-4-aminopyrazolopyrimidine, with a number of nucleophilic reagents.The cytotoxic activities of the compounds obtained were studied.
