902172-06-9

Upstream product

• 1034498-78-6 (2R)-(-)-2-n-butyl-5-oxopyrrolidine-1-carboxylic acid benzyl ester 
• 64-17-5 ethanol 
• 98-79-3 L-Pyroglutamic acid 
• 136092-38-1 (R)-5-n-Butyl-2-pyrrolidinone 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 72120-43-5 (-)-(3R,5S,8aS)-3-butyl-5-propylindolizidine 
• 67217-85-0 (-)-indolizidine 223AB 

Relevant academic research and scientific papers

Asymmetric synthesis of 3,5-disubstituted indolizidines by intermolecular addition of an allylsilane on an N-acyliminium ion

A diastereoselective synthesis of 3,5-disubstituted indolizidines based on an intermolecular addition of an allylsilane on an acyliminium ion derived from (S)-pyroglutamic acid is described. The synthetic potential of this methodology is demonstrated by t