90238-10-1

Usage

Uses

Used in Pharmaceutical Industry:
N,N-DIMETHYL-3-(TRIFLUOROMETHYL)BENZAMIDE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, N,N-DIMETHYL-3-(TRIFLUOROMETHYL)BENZAMIDE is utilized as an intermediate in the production of agrochemicals, which are essential for enhancing crop protection and yield.
Used as a Reagent in Organic Synthesis:
N,N-DIMETHYL-3-(TRIFLUOROMETHYL)BENZAMIDE is employed as a reagent in organic synthesis, where its unique structure allows for specific reactions that can lead to the formation of complex organic molecules.
Used as a Building Block in Chemical Reactions:
N,N-DIMETHYL-3-(TRIFLUOROMETHYL)BENZAMIDE also serves as a building block in various chemical reactions, enabling the creation of a wide range of chemical products for different industries.

InChI:InChI=1/C10H10F3NO/c1-14(2)9(15)7-4-3-5-8(6-7)10(11,12)13/h3-6H,1-2H3

Upstream product

• 129946-88-9 Umemoto's reagent 
• 68-12-2 N,N-dimethyl-formamide 
• 2338-76-3 3-trifluoromethylphenylacetonitrile 
• 506-59-2 N,N-dimethylammonium chloride 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 127-19-5 N,N-dimethyl acetamide 
• 201230-82-2 carbon monoxide 

Downstream Products

• 454-92-2 3-(trifluoromethyl)benzoic acid 

Relevant academic research and scientific papers

Copper-catalyzed formation of N,N-dimethyl benzamide from nitrile and DMF under an O2 atmosphere

Amidation of nitrile with N,N-dimethylformamide (DMF) was catalyzed by Cu2O with 1,10-phenanthroline as a ligand under an oxygen atmosphere. A variety of N,N-dimethyl benzamides were obtained in yields up to 84%.

Copper-catalyzed trifluoromethylation of aryl boronic acids using a CF 3+ reagent

A copper-catalyzed process for trifluoromethylation of aryl, heteroaryl, and vinyl boronic acids has been developed. The reaction is conducted under mild conditions and shows tolerance to moisture and a variety of functional groups.

BIARYL PIPERAZINYL-PYRIDINE ANALOGUES

Biaryl piperazinyl -pyri dine analogues are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands, for receptor localization studies.

Synthesis of primary aromatic amides by aminocarbonylation of aryl halides using formamide as an ammonia synthon

Primary aromatic amides were prepared by a palladium-catalyzed aminocarbonylation reaction of aryl halides in high yields (70-90%) using formamide as the amine source. The reactions require a palladium catalyst in combination with a nucleophilic Lewis base such as imidazole or 4-(dimethylamino)pyridine (DMAP). Aryl, heteroaryl, and vinyl bromides and chlorides were converted to the primary amides under mild conditions (5 bar, 120 °C) using 1 mol % of a palladium-phosphine complex. Best results were obtained in dioxane using triphenylphosphine as the ligand and DMAP as the base. For activated aryl bromides, a phosphine-to-palladium ratio of 2:1 was sufficient, but less reactive aryl bromides or aryl chlorides required ligand-to-palladium ratios up to 8:1 in order to stabilize the catalyst and achieve full conversion. The influence of catalyst, base, solvent, pressure, and temperature was studied in detail. The mechanism of the. reaction could be clarified by isolating and identifying the reaction intermediates. In addition, methylamides and dimethylamides were prepared by the same method using N-methylformamide and N,N-dimethylformamide as the amine source.