90252-76-9Relevant articles and documents
Optical Resolution and Determination of Absolute Configuration of (=/-)-2-propionic Acids
Naruto, Shunji,Terada, Atsusuke
, p. 4286 - 4294 (2007/10/02)
The title compound, which was newly synthesized, showed good anti-inflammatory and analgesic activities.Optical resolution was performed by the following procedures: 1) condensation of the acid with (-)-1-phenylethylamine followed by separation of diasteromeric amides; 2) reduction of the cyclopentanone moiety and then acylation with optically active acid; 3) separation of epimeric esters followed by saponification of esters; 4) oxidation of alcohols to ketones; 5) saponification of amides.The absolute configurations of the four optically active compounds thus obtained were confirmed by circular dichroism spectroscopy.Keywords -- antiflammatory agent; 2-arylpropionic acid derivative; optical resolution; absolute configuration; CD; ORD