90252-77-0

Basic information

• Product Name: (-)-N-<(1S)-1-phenylethyl>-(2R)-2-<4-(cis-2-hydroxycyclopentylmethyl)phenyl>propionamide
• CAS NO: 90252-77-0
• Molecular Weight: 351.489
• Mol File: 90252-77-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (-)-N-<(1S)-1-phenylethyl>-(2R)-2-<4-(cis-2-hydroxycyclopentylmethyl)phenyl>propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-N-<(1S)-1-phenylethyl>-(2R)-2-<4-(cis-2-hydroxycyclopentylmethyl)phenyl>propionamide(90252-77-0)
• EPA Substance Registry System: (-)-N-<(1S)-1-phenylethyl>-(2R)-2-<4-(cis-2-hydroxycyclopentylmethyl)phenyl>propionamide(90252-77-0)

Safety Data

• Hazardous Substances Data: 90252-77-0(Hazardous Substances Data)

Upstream product

• 90252-78-1 (-)-N-<(1S)-1-phenylethyl>-(2R)-2-<4-cyclopentylmethyl>phenyl>propionamide 
• 90252-78-1 (-)-N-<(1S)-1-phenylethyl>-(2R)-2-<4-cyclopentylmethyl>phenyl>propionamide 
• 68767-14-6 loxoprofen 
• 83599-41-1 (-)-N-<(1S)-1-phenylethyl>-(2R)-2-<4-(2-oxocyclopentylmethyl)phenyl>propionamide 
• 83599-41-1 (-)-N-<(1S)-1-phenylethyl>-(2S)-2-<4-(2-oxocyclopentylmethyl)phenyl>propionamide 
• 90252-77-0 (-)-N-<(1S)-1-phenylethyl>-(2R)-2-<4-(cis-2-hydroxycyclopentylmethyl)phenyl>propionamide 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 90319-78-1 (2S)-2-<4-((1S)-2-oxocyclopentylmethyl)phenyl>propionic acid 
• 83599-42-2 (2S)-2-<4-((1R)-2-oxocyclopentylmethyl)phenyl>propionic acid 
• 90319-73-6 (2R)-2-<4-((1S)-2-oxocyclopentylmethyl)phenyl>propionic acid 
• 90319-74-7 (2R)-2-<4-((1R)-2-oxocyclopentylmethyl)phenyl>propionic acid 
• 90252-77-0 (-)-N-<(1S)-1-phenylethyl>-(2S)-<4-phenyl>propionamide 
• 90252-77-0 (-)-N-<(1S)-1-phenylethyl>-(2S)-<4-phenyl>propionamide 
• 90252-77-0 (-)-N-<(1S)-1-phenylethyl>-(2R)-<4-phenyl>propionamide 
• 90252-77-0 (-)-N-<(1S)-1-phenylethyl>-(2R)-<4-phenyl>propionamide 
• 83599-41-1 (S)-2-[4-((S)-2-Oxo-cyclopentylmethyl)-phenyl]-N-(1-phenyl-ethyl)-propionamide 
• 83599-41-1 (S)-2-[4-((R)-2-Oxo-cyclopentylmethyl)-phenyl]-N-(1-phenyl-ethyl)-propionamide 
• 83599-41-1 (R)-2-[4-((S)-2-Oxo-cyclopentylmethyl)-phenyl]-N-(1-phenyl-ethyl)-propionamide 
• 83599-41-1 (R)-2-[4-((R)-2-Oxo-cyclopentylmethyl)-phenyl]-N-(1-phenyl-ethyl)-propionamide 
• 90252-78-1 (-)-N-<(1S)-1-phenylethyl>-(2S)-2-<4-cyclopentylmethyl>phenyl>propionamide 
• 90252-78-1 (-)-N-<(1S)-1-phenylethyl>-(2S)-2-<4-cyclopentylmethyl>phenyl>propionamide 

Relevant articles and documents

Optical Resolution and Determination of Absolute Configuration of (=/-)-2-propionic Acids

The title compound, which was newly synthesized, showed good anti-inflammatory and analgesic activities.Optical resolution was performed by the following procedures: 1) condensation of the acid with (-)-1-phenylethylamine followed by separation of diasteromeric amides; 2) reduction of the cyclopentanone moiety and then acylation with optically active acid; 3) separation of epimeric esters followed by saponification of esters; 4) oxidation of alcohols to ketones; 5) saponification of amides.The absolute configurations of the four optically active compounds thus obtained were confirmed by circular dichroism spectroscopy.Keywords -- antiflammatory agent; 2-arylpropionic acid derivative; optical resolution; absolute configuration; CD; ORD