90254-20-9Relevant academic research and scientific papers
CATHEPSIN CYSTEINE PROTEASE INHIBITORS
-
Page/Page column 54, (2015/04/28)
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
CATHEPSIN CYSTEINE PROTEASE INHIBITORS
-
Page/Page column 48, (2015/04/28)
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
HETEROCYCLIC COMPOUND
-
Paragraph 0921, (2015/04/15)
The present invention provides a compound having a superior JAK inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like, or a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
CATHEPSIN CYSTEINE PROTEASE INHIBITORS
-
Page/Page column 45, (2015/09/22)
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is i
Dipole Moments of Some N-Phenyl-substituted Derivatives of Pyrrolidine, Piperidine, Morpholine, and Thiomorpholine
Beach, Steven F.,Hepworth, John D.,Sawyer, John,Hallas, Geoffrey,Marsden, Richard,et al.
, p. 217 - 222 (2007/10/02)
Apparent dipole moments in benzene of various p-substituted N-phenyl derivatives of pyrrolidine, piperidine, morpholine, and thiomorpholine and of some analogous NN-diethylanilines have been determined.Vector moments along the bisector of angle CH2NCH2 and also in the direction of the major axis of the aromatic ring have been calculated for the parent compounds.The order of magnitude of the latter is N-phenylpyrrolidine>NN-diethylaniline>N-phenylpiperidine>N-phenylmorpholine>N-phenylthiomorpholine.The nature of the heterocycle does not greatly affect the additional moment, μ(add.), along the major axis of the aromatic ring, required to account for the moments of the p-substituted compounds.In each series of compounds, μ(add.) parallels the Hammett substituent constant, ?.
