902750-98-5

Basic information

• Product Name: Bicyclo[2.2.1]heptan-2-one, 3-[[3,5-bis(trifluoromethyl)phenyl]methylene]-1,7,7-trimethyl-, (1R,3E,4S)-
• CAS NO: 902750-98-5
• Molecular Formula: C19H18F6O
• Molecular Weight: 376.342
• Mol File: 902750-98-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Bicyclo[2.2.1]heptan-2-one, 3-[[3,5-bis(trifluoromethyl)phenyl]methylene]-1,7,7-trimethyl-, (1R,3E,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Bicyclo[2.2.1]heptan-2-one, 3-[[3,5-bis(trifluoromethyl)phenyl]methylene]-1,7,7-trimethyl-, (1R,3E,4S)-(902750-98-5)
• EPA Substance Registry System: Bicyclo[2.2.1]heptan-2-one, 3-[[3,5-bis(trifluoromethyl)phenyl]methylene]-1,7,7-trimethyl-, (1R,3E,4S)-(902750-98-5)

Safety Data

• Hazardous Substances Data: 902750-98-5(Hazardous Substances Data)

Upstream product

• 112981-69-8 3,5-bis(trifluoromethyl)phenylmagnesium bromide 
• 473929-46-3 (1R,4R)-3-[(E)-(dimethylamino)methylidene]-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one 

Relevant articles and documents

Stereoselective additions to the exocyclic C{double bond, long}C bond of some α-alkylidene-(+)-camphor derivatives

Stereoselective additions to the exocyclic C{double bond, long}C double bond of some (1R,3E,4S)-3-alkylidene-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ones and (1R,4E,5S)-4-alkylidene-1,8,8-trimethyl-2-oxabicyclo[3.2.1]octan-3-ones were studied. All additions took place predominantly from the less hindered endo-face of the methylidene compounds to give the corresponding exo-adducts as the major isomers. Thus, catalytic hydrogenations afforded the α-alkylated (1R,3R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ones and (1R,4R,5R)-1,8,8-trimethyl-2-oxabicyclo[3.2.1]octan-3-ones in 28-100% de. Similarly, 1,3-dipolar cycloadditions of 2,4,6-trisubstituted benzonitrile oxides gave the corresponding spiro cycloadducts in 66-100% de. The structures were determined by 2D NMR techniques, NOESY spectroscopy and X-ray diffraction.