90287-02-8

Upstream product

• 23378-88-3 3,5-dichloro-2-hydroxybenzenesulfonyl chloride 
• 120-83-2 2,4-dichlorophenol 

Downstream Products

• 90287-08-4 C₁₄H₁₂Cl₂N₂O₅S 
• 90287-07-3 C₁₃H₁₀Cl₂N₂O₄S 
• 95087-70-0 C₁₀H₁₂Cl₂N₂O₃S 
• 95087-72-2 2,4-Dichloro-6-(3,5-dimethyl-pyrazole-1-sulfonyl)-phenol 
• 95087-69-7 C₉H₁₀Cl₂N₂O₃S 
• 90287-06-2 C₁₃H₁₀Cl₂N₂O₄S 

Relevant academic research and scientific papers

Synthesis, in vitro α-amylase inhibitory, and radicals (DPPH & ABTS) scavenging potentials of new N-sulfonohydrazide substituted indazoles

Over-expression of α-amylase enzyme causes hyperglycemia which lead to many physiological complications including oxidative stress, one of the most commonly associated problem with diabetes mellitus. Marketed α-amylase inhibitors such as acarbose, voglibose, and miglitol used to treat type-II diabetes mellitus, but also linked to several harmful effects. Therefore, it is essential to explore new and nontoxic antidiabetic agents with additional antioxidant properties. In this connection, a series of new N-sulfonohydrazide substituted indazoles 1–19 were synthesized by multistep reaction scheme and assessed for in vitro α-amylase inhibitory and radical (DPPH and ABTS) scavenging properties. All compounds were fully characterized by different spectroscopic techniques including 1H, 13C NMR, EI-MS, HREI-MS, ESI-MS, and HRESI-MS. Compounds showed promising α-amylase inhibitory activities (IC50 = 1.23 ± 0.06–4.5 ± 0.03 μM) as compared to the standard acarbose (IC50 1.20 ± 0.09 μM). In addition to that all derivatives were found good to moderate scavengers of DPPH (IC50 2.01 ± 0.13–5.3 ± 0.11) and ABTS (IC50 = 2.34 ± 0.07–5.5 ± 0.07 μM) radicals, in comparison with standard ascorbic acid having scavenging activities with IC50 = 1.99 ± 0.09 μM, and IC50 2.03 ± 0.11 μM for DPPH and ABTS radicals. In silico molecular docking study was conducted to rationalize the binding interaction of α-amylase enzyme with ligands. Compounds were observed as mixed type inhibitors in enzyme kinetic characterization.

Chlorosulfonation of Some Aromatic Compounds

Dibenzylideneacetone, biphenyl, o-toluanilide, 5-chlorosalicylic acid, and 2,4-, 2,5- and 3,5-dichlorophenol have been reacted with chlorosulfonic acid and the sulfonyl chlorides thus obtained have been characterized by reaction with nucleophilic reagents; in the case of the dichlorophenols the orientation has been confirmed by PMR spectroscopy.The results of preliminary antibacterial and fungicidal screening are included.