90290-22-5

Upstream product

• 100-39-0 benzyl bromide 
• 90290-07-6 1-((2R,5R)-2,5-Bis-methoxymethyl-pyrrolidin-1-yl)-propan-1-one 
• 90290-05-4 (2R,5R)-2,5-bis(methoxymethyl)pyrrolidine 

Relevant academic research and scientific papers

Synthesis of optically active azetidine-2,4-dicarboxylic acid and related chiral auxiliaries for asymmetric synthesis

(S)-1-Phenylethylamine has been used as a chiral auxiliary as well as a nitrogen atom donor in the synthesis of an enantiomeric pair of azetidine-2,4-dicarboxylic acids, the absolute configuration of one of which has been assigned on the basis of the X-ra

ASYMMETRIC ALKYLATION OF CARBOXYAMIDES BY USING trans-2,5-DISUBSTITUTED PYRROLIDINES AS CHIRAL AUXILIARIES

trans-2,5-Bis(methoxymethyl)- and trans-2,5-bis(methoxymethoxymethyl)pyrrolidines proved to be excellent chiral auxiliaries for the asymmetric alkylation of the corresponding carboxyamide enolates giving good chemical yield and high stereoselectivity (invariably over 95percent de), with remarkable flexibility to substrates and reaction conditions.