90296-05-2Relevant academic research and scientific papers
Perfluororganochalkogeno-ketene. III. Bis(pentafluorphenylsulfanyl)keten (C6F5S)2C=C=O; Synthesen und Charakterisierung
Haas, Alois,Praas, Hans-Walter,Radau, Godehard
, p. 257 - 260 (2007/10/02)
Bis(pentafluorophenylsulfanyl)ketene (1) may be prepared in good yield by the dehydration of the corresponding substituted acetic acid (C6F5S)2CHC(O)OH (4b) with P4O10 or by the reaction of C6F5SCl with Ag2CCO.The starting material 4b is prepared from CH3C(OCH2CH3)3 and C6F5SCl.Acidolysis of the C6F5S-substituted orthoesters 2 provided the ethyl esters CH3-n(SC6F5)nC(O)OCH2CH3 (3) and acetic acids CH3-n(SC6F5)nC(O)OH (4).
Design, Synthesis, and Testing of Potential Antisickling Agents. 4. Structure-Activity Relationships of Benzyloxy and Phenoxy Acids
Abraham, D. J.,Kennedy, P. E.,Mehanna, A. S.,Patwa, D. C.,Williams, F. L.
, p. 967 - 978 (2007/10/02)
In this paper we further establish the activity of two classes of small molecules, benzyloxy and phenoxy acids, as potent inhibitors of hemoglobin S (HbS) gelation.Structural modifications with a large number of each class confirm our earlier work that the highest activity is observed with compounds that contain dihalogenated aromatic rings with attached polar side chains.We have also found a halogenated aromatic malonic acid derivative to be quite active.Compounds reported in this paper are compared with other antigelling agents studied in our laboratory.Comments are made concerning the antigelling activity and binding sites of four derivatives and their effect on the allosteric mechanism of hemoglobin (Hb) function.
