90330-15-7Relevant articles and documents
A Convenient Synthesis of Pyridoxine
Shimada, Sadakatsu,Oki, Masaharu
, p. 38 - 43 (2007/10/02)
A novel and convenient synthesis of pyridoxine starting from N-(1-cyanoethyl)formamide is described.The reaction of N-(cyanoethyl)acylamides with olefins in the presence of an acid catalyst gave 3-amino-2-methylpyridines.Similar reaction of N-(1-cyanoethyl)formamide with fumaronitrile in the presence of trifluoroacetic acid afforded 5-amino-6-methylpyridine-3,4-dicarbonitrile, which was easily converted to pyridoxine by reduction and diazotization.Keywords - N-(1-cyanoethyl)acylamide; fumaronitrile; 3-amino-2-methylpyridine; 3-cyano-2-propen-1-yl acetate; pyridoxine