90331-02-5

Upstream product

• 114655-48-0 (E)-2-methyl-N-((E)-3-phenylallylidene)propan-2-amine 
• 14371-10-9 (E)-3-phenylpropenal 
• 594-70-7 2-Methyl-2-nitropropane 
• 57497-39-9 N-tertbutylhydroxylamine hydrochloride 
• 136809-07-9 1-tert-butyl-4-phenyl-1-aza-1,3-butadiene 
• 90330-97-5 (E)-2-(tert-butyl)-3-styryl-1,2-oxaziridine 

Downstream Products

• 1152672-26-8 (5-butyl-2-tert-butyl-3-styryl-2,3-dihydro-isoxazol-4-yl)-phenyl-methanone 
• 1383738-71-3 (S,E)-2-tert-butyl-5-phenyl-3-styryl-2,3-dihydroisoxazole-4-carbaldehyde 

Relevant academic research and scientific papers

Stereoselective synthesis of fluoroalkenoates and fluorinated isoxazolidinones: N-substituents governing the dual reactivity of nitrones

α-Fluoroalkenoates and 4-fluoro-5-isoxazolidinones are of vast interest due to their potential biological applications. We now demonstrate the syntheses of (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones by the reactions between nitrones and α-fluoro-α-bromoacetate. By altering N-substituents in nitrones, (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones can be achieved, respectively, with high chemo- and stereoselectivities. Experimental and computational studies have been conducted to elucidate the reaction mechanisms. Linear free energy relationship studies further revealed that the N-substituent effects are primarily of electronic origin. Copyright

A torquoselective extrusion of isoxazoline N-oxides. Application to the synthesis of aryl vinyl and divinyl ketones for Nazarov cyclization

A mild, convenient reaction sequence for the synthesis of Nazarov cyclization substrates is described. The [3+2] dipolar cycloaddition of a nitrone and an electron-deficient alkyne gives an isolable isoxazoline intermediate, which upon oxidation undergoes stereoselective extrusion of nitrosomethane to give aryl vinyl or divinyl ketones.

Nitrone derivatives

A compound represented by the figure (1) or a pharmaceutically acceptable salt thereof is useful as medicament for treating retinal degenerative disorders: wherein Ar is optionally substitued phenyl or optionally substituted heteroaryl;. n is 0, 1 or 2; W

Synthesis of 2-Alkyl-3-vinyloxaziridines as Potential Antitumor Agents

A convenient method for the synthesis of previously unknown oxaziridines having unsaturated substituents at the 3-position (3a - k) is based on the selective oxidation of the imino group of α,β-unsaturated aldimines 2 with m-chloroperbenzoic acid.The titl

1-AZADIENES AS A SYNTHON FOR HETEROCYCLIC SYNTHESIS

1-Azabutadienes 1 were found to be a good building block for three- to five-membered heterocycles having a functional group.Oxidation of 1 with mCPBA afforded 3-alkenyloxaziridines 2.Cycloaddition of 1 with ketenes gave the 4-alkenylazetidinones 6.Addition of a nitrile imine occured across the C=N bond to give the 3-alkenyltriazoline 8, while that of a nitrile ylide occurred on the C=C bond to give the 3-formylpyrrole 14 formed by hydrolysis of the C=N bond.