90330-97-5Relevant academic research and scientific papers
Synthesis of 4-Isoxazolines via Visible-Light Photoredox-Catalyzed [3 + 2] Cycloaddition of Oxaziridines with Alkynes
Jang, Gwang Seok,Lee, Junggeun,Seo, Jungseok,Woo, Sang Kook
supporting information, p. 6448 - 6451 (2017/12/08)
A method for [3 + 2] cycloaddition of oxaziridines with alkynes to form 4-isoxazolines via visible-light photoredox catalysis is described. This method is a greener, atom-economical reaction that tolerates various functional groups and provides good to excellent yield. Moreover, the cyclization products can be conveniently converted into tetrasubstituted allylic alcohols and enamines. A mechanistic study suggests that the reaction involves photoredox-catalyzed in situ generation of a nitrone from the oxaziridine by SET.
Synthesis of 2-Alkyl-3-vinyloxaziridines as Potential Antitumor Agents
Said, Samy B.,Mlochowski, Jacek,Skarzewski, Jacek
, p. 461 - 464 (2007/10/02)
A convenient method for the synthesis of previously unknown oxaziridines having unsaturated substituents at the 3-position (3a - k) is based on the selective oxidation of the imino group of α,β-unsaturated aldimines 2 with m-chloroperbenzoic acid.The titl
1-AZADIENES AS A SYNTHON FOR HETEROCYCLIC SYNTHESIS
Ohshiro, Yoshiki,Komatsu, Mitsuo,Uesaka, Masatoshi,Agawa, Toshio
, p. 549 - 559 (2007/10/02)
1-Azabutadienes 1 were found to be a good building block for three- to five-membered heterocycles having a functional group.Oxidation of 1 with mCPBA afforded 3-alkenyloxaziridines 2.Cycloaddition of 1 with ketenes gave the 4-alkenylazetidinones 6.Addition of a nitrile imine occured across the C=N bond to give the 3-alkenyltriazoline 8, while that of a nitrile ylide occurred on the C=C bond to give the 3-formylpyrrole 14 formed by hydrolysis of the C=N bond.
