90345-62-3Relevant academic research and scientific papers
Photodeoxygenation of dibenzothiophene S-oxide derivatives in aqueous media
Korang, James,Grither, Whitney R.,McCulla, Ryan D.
supporting information; experimental part, p. 4466 - 4476 (2010/06/13)
The use of atomic oxygen (O(3P)) as potent oxidant In water has suffered from the lack of a facile, efficient source. The photodeoxygenatlon of aromatic sulfoxides to the corresponding sulfides in organic solvents has been suggested to produce O(3P) in low quantum yields. The photolysis of 4,6-dihydroxymethyldibenzothiophene S-oxide and 2,8- dihydroxymethyldibenzothiophene S-oxide in water results in deoxygenation at significantly higher quantum yields than In organic solvents. Depending upon conditions, a variable amount of oxidation of the hydroxymethyl substituent into an aldehyde was observed to accompany deoxygenation. Analysis of the photoproducts Indicated the deoxygenation occurred by at least two different pH-sensitive mechanisms. Under basic conditions, photoinduced electron transfer yielding a hydroxysulfuranyl radical that decomposed by heterolytlc S-O cleavage was thermodynamically feasible. The thermodynamics of photoinduced electron transfer were expected to become increasingly unfavorable as the pH of the solution decreased. Thus, at neutral and acidic pH, an S-O bond scission mechanism was suspected. The observed increase In the photodeoxygenation quantum yields was consistent with charge separation accompanying S-O bond scission. Oxidative cleavage of alkenes In aerobic conditions suggested O(3P) was produced during photolysis In these conditions; however, the formation of discrete O-/HO may occur, particularly at low pH.
SULFOXIMINES AS KINASE INHIBITORS
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Page/Page column 96-97, (2008/12/05)
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
Asymmetric sulfoxidation catalyzed by a vanadium bromoperoxidase: Substrate requirements of the catalyst
Andersson, Malin A.,Allenmark, Stig G.
, p. 15293 - 15304 (2007/10/03)
An investigation of the catalytic effect of vanadium bromoperoxidase (VBrPO, from Corallina officinalis) on the oxidation of a series of prochiral sulfides by hydrogen peroxide, revealed that substrates having a cis- positioned carboxyl group are oxidized
